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ProteomicsEGF Induces Migration Independent of EMT or Invasion in A549 Lung Adenocarcinoma Cells
Tumors and tumor surrounding tissues produce multiple growth factors that influence tumor cell behavior via different signal transduction pathways. Growth factors like transforming growth factor beta (TGFβ) and epidermal growth factor (EGF) were shown to induce proliferation, migration and invasion ...
ORGANISM(S): Homo sapiens (Human) 
2021-04-08 | PXD023024 | Pride
Human Invasiveness Epithelial to mesenchymal transition Tgfβ Lung adenocarcinoma Egf Cancer cell migration 
ProteomicsProteome Profiling Identifies Markers for Inflammation-Related Tumor-Fibroblast Interaction in Colorectal Cancer
Inflammation has been identified as an important factor in cancer development and progression, including colorectal cancer [CRC]. To determine the role of inflammation and the specific contribution of activated fibroblasts in cancer development and progression we analyzed six human CRC tissue specim...
ORGANISM(S): Homo sapiens (Human) 
2018-10-17 | PXD006776 | Pride
Tissue proteomics Shotgun proteomics Mass spectrometry Colorectal cancer Q exactive orbitrap 
ProteomicsLipid class-specific kinetics of plasma fatty acids, oxylipins, endocannabinoids, lysophospholipids and bile acids upon a lipopolysaccharide challenge of healthy humans and their modulation by anti-oxidative supplements
While molecular mechanisms of inflammatory processes are well characterized, the systemic responses of humans exposed to pathogen-associated molecular pattern with regard to fatty acid derivatives and other lipids have hardly been determined. Here, we present a dual stage controlled clinical interve...
ORGANISM(S): Homo sapiens (Human) 
2025-06-02 | PXD051013 | Pride
Lipopolysaccharide Time series analysis Inflammation Lipidomics Lipid mediators Plasma Anti-oxidative supplements Clinical study 
ProteomicsPlasma Instead of Serum Avoids Critical Confounding of Clinical Metabolomics Studies by Platelets – secretome of platelets
Metabolomics is an emerging and powerful bioanalytical method supporting clinical investigations. Serum and plasma are commonly used without rational prioritization. Serum is collected after blood coagulation, a complex biochemical process involving active platelet metabolism. This may affect the me...
ORGANISM(S): Homo sapiens (Human) 
2024-03-25 | PXD041785 | Pride
Confounder Platelets Proteomics Metabolomics Lc-ms Plasma Serum Drug effects 
ProteomicsMultilevel Omics-Readouts of Perturbation Studies in vitro are Determined by Memory Effects from Subculture
Mass spectrometry-based omics technologies are of increasing relevance for drug discovery. In order to map drug treatments to biological pathways for mode of action (MoA) deconvolution, they rely on the determination of multiple testing corrected significant molecular events. The main contributors t...
ORGANISM(S): Homo sapiens (Human) 
2025-04-22 | PXD051069 | Pride
Phosphoproteomics Reproducibility Multi-level omics Subculture Arsenic trioxide Mode of action deconvolution Proteomics Perturbation network Eicosadomics 
ProteomicsMultilevel Omics-Readouts of Perturbation Studies in vitro are Determined by Memory Effects from Subculture
Mass spectrometry-based omics technologies are of increasing relevance for drug discovery. In order to map drug treatments to biological pathways for mode of action (MoA) deconvolution, they rely on the determination of multiple testing corrected significant molecular events. The main contributors t...
ORGANISM(S): Homo sapiens (Human) 
2025-04-22 | PXD039768 | Pride
Phosphoproteomics Reproducibility Multi-level omics Subculture Arsenic trioxide Mode of action deconvolution Proteomics Perturbation network Eicosadomics 
ProteomicsPlasma Instead of Serum Avoids Critical Confounding of Clinical Metabolomics Studies by Platelets – serum and plasma
Metabolomics is an emerging and powerful bioanalytical method supporting clinical investigations. Serum and plasma are commonly used without rational prioritization. Serum is collected after blood coagulation, a complex biochemical process involving active platelet metabolism. This may affect the me...
ORGANISM(S): Homo sapiens (Human) 
2024-03-25 | PXD041781 | Pride
Confounder Platelets Proteomics Metabolomics Lc-ms Plasma Serum Drug effects 
ProteomicsBOLD-100 treatment induces systemic lipid crosstalk in metastatic colorectal carcinoma patients in a combination treatment with FOLFOX
BOLD-100 (sodium trans-[tetrachlorobis (1H-indazole)ruthenate(III)]) is a clinical stage anticancer drug candidate that targets GRP78 and impacts the ER stress responses in cancer cells. Despite expanding knowledge about its multimodal mechanism of action from preclinical studies, little is known ab...
ORGANISM(S): Homo sapiens (Human) 
2026-07-27 | PXD069599 | Pride
Bold-100  cancer  drug development  fatty acids  folfox  kp1339  multi-omics  metals in medicine  oxylipins  plasma  proteomics 
ProteomicsPrimary and hTERT-transduced mesothelioma-associated fibroblasts but not primary or hTERT-transduced mesothelial cells stimulate growth of human mesothelioma cells_ Cytoplasmic proteins & Proteins from nuclear extracts
Introduction: Pleural mesothelioma (PM) is known as one of the most aggressive malignancies among all cancers, despite of usually absent tumor-driver mutations in oncogenes. It develops in a unique inflammatory tumor microenvironment (TME), which has been postulated as major contributor of PM’s high...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD043534 | Pride
Htert Mesothelioma-associated fibroblasts Pleural mesothelial cells Pleural mesothelioma Conditioned medium Human telomerase reverse transcriptase Tumor microenvironment 
ProteomicsPrimary and hTERT-transduced mesothelioma-associated fibroblasts but not primary or hTERT-transduced mesothelial cells stimulate growth of human mesothelioma cells_Secreted proteins
Introduction: Pleural mesothelioma (PM) is known as one of the most aggressive malignancies among all cancers, despite of usually absent tumor-driver mutations in oncogenes. It develops in a unique inflammatory tumor microenvironment (TME), which has been postulated as major contributor of PM’s high...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD043511 | Pride
Htert Mesothelioma-associated fibroblasts Pleural mesothelial cells Pleural mesothelioma Conditioned medium Human telomerase reverse transcriptase Tumor microenvironment 
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