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MetabolomicsInositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-Golgi contact sites
Vesicular traffic and membrane contact sites between organelles enable the exchange of proteins, lipids, and metabolites. Recruitment of membrane tethers to contact sites between the endoplasmic reticulum (ER) and the plasma membrane is often triggered by calcium. In contrast, we reveal here a funct...
2021-05-06 | MTBLS2444 | MetaboLights
GenomicsNucleosome exchange in budding yeast
Nucleosome exchange in budding yeast
PRJNA661212 | ENA
ProteomicsMolecular mechanism of exchange coupling in CLC chloride/proton antiporters
The ubiquitous CLC membrane transporters are the only transporter family known to exchange anions for cations. Despite extensive study, there is no model to completely explain the 2:1 Cl‒/H+ stoichiometric exchange mechanism. Here, we provide such a model. Using CLC-ec1, a bacterial homolog that has...
ORGANISM(S): Escherichia coli 
2025-07-21 | PXD058693 | Pride
Mass spectrometry Protein structure Membrane proteins H/d exchange Proton-chloride antiporter 
MetabolomicsIntegrated analysis of transcriptome and metabolome reveals molecular responses to ammonia stress in the gills of Litopenaeus vannamei under low-salinity conditions

High ammonia nitrogen stress significantly compromises the survival of Litopenaeus vannamei under low-salinity conditions, posing a common challenge in low-salinity aquaculture. However, existing studies predominantly focus on ammonia nitrogen responses unde...

2026-04-10 | MTBLS14054 | MetaboLights
GenomicsRegulators of histone exchange
Regulators of histone exchange
PRJNA927495 | ENA
ProteomicsMolecular basis for differential activation of p101 and p84 complexes of PI3Kg by Ras and GPCRs
Using hydrogen deuterium exchange mass spectrometry, we reveal molecular differences between the two p110g-p84 and p110g-p101 complexes that explain their differential activation.
ORGANISM(S): Homo sapiens (Human) 
2023-03-09 | PXD035723 | Pride
Pi3kg P101 Ras P110g Hdx-ms Hdx Gby 
ProteomicsStructural and mechanistic insights into the CAND1-mediated SCF substrate receptor exchange
Modular SCF (SKP1-CUL1-Fbox) ubiquitin E3 ligases orchestrate multiple cellular pathways in eukaryotes. Their variable SKP1-Fbox substrate receptor (SR) modules enable regulated substrate recruitment and subsequent proteasomal degradation. CAND proteins are essential for the efficient and timely exc...
ORGANISM(S): Homo sapiens (Human) 
2023-09-18 | PXD042178 | Pride
Human Cand1 Cryo-em Hdx-ms 
TranscriptomicsThe Rho Exchange Factors Vav2 and Vav3 Control a Lung MetastasisM-bM-^@M-^SSpecific Transcriptional Program in Breast Cancer Cells
The guanosine triphosphatases of the Rho and Rac subfamilies regulate protumorigenic pathways and are activated by guanine nucleotide exchange factors (Rho GEFs), which could be potential targets for anticancer therapies. We report that two Rho GEFs, Vav2 and Vav3, play synergistic roles in breast c...
ORGANISM(S): Mus musculus 
2012-10-03 | E-GEOD-33348 | biostudies-arrayexpress
ProteomicsAnion-Exchange Chromatography of Tryptic and Phosphopeptides: WAX vs. SAX and AEX vs. ERLIC
At a pH > 5, phosphopeptides have two negative charges per residue and are well-retained in anion-exchange chromatography. However, the peptides with one or two phosphate groups are not separated from the peptides with multiple Asp or Glu residues, which interfere with the identification of phosph...
ORGANISM(S): Homo sapiens (Human) 
2015-04-23 | PXD001333 | Pride
Chromatography erlic sax wax aex 
ProteomicsFam170a deficiency causes male infertility by impairing histone-to-protamine exchange during mouse spermiogenesis
Families with sequence similarity 170 members A (Fam170a) deficiency caused abnormal sperm nuclear morphology and male infertility in mice, mirroring the observation of very low Fam170a transcription in sperm of infertile men with teratozoospermia.Fam170a directly interacted with the deubiquitinatin...
ORGANISM(S): Mus Musculus 
2024-11-10 | PXD057721 |
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