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MetabolomicsUnraveling the Heterogeneity of Hyperuricemia Using Untargeted Metabolomics and Statistical Modeling

Background. Hyperuricemia is the second most prevalent metabolic disorder globally and exhibits pronounced heterogeneity in clinical practice. Only about 10% of individuals with asymptomatic hyperuricemia (HUA) progress to gout, yet the lack of specific biomarkers and precise therapeutic targets ...

2025-10-05 | MTBLS13094 | MetaboLights
MetabolomicsNormalization techniques for PARAFAC modeling of urine metabolomics data
One of the body fluids often used in metabolomics studies is urine. The peak intensities of metabolites in urine are affected by the urine history of an individual resulting in dilution differences. This requires therefore normalization of the data to correct for such differences. Two normalization ...
2017-05-11 | MTBLS290 | MetaboLights
MetabolomicsMolecular structural diversity of mitochondrial cardiolipins
Current strategies used to quantitatively describe the biological diversity of lipids by mass spectrometry are often limited in assessing the exact structural variability of individual molecular species in detail. A major challenge is represented by the extensive isobaric overlap present among lipid...
2021-01-11 | MTBLS636 | MetaboLights
MetabolomicsClinacanthus nutans fractions exert anti-nasopharyngeal carcinoma effects: integrating untargeted metabolomics, network pharmacology, molecular docking and experimental validation

Background: Clinacanthus nutans (C. nutans), a Southeast Asian medicinal herb, has ethnopharmacological potential against nasopharyngeal carcinoma (NPC). This study aimed to elucidate the bioactive compounds, potential molecular targets, and regulatory pathways responsible for the anticancer acti...

2026-01-05 | MTBLS13610 | MetaboLights
MetabolomicsOral administration of low-molecular-weight heparin ameliorates colitis by enhancing the gut mucus barrier via microbial tryptophan metabolites

Background and Purpose: Previous studies have reported that oral low molecular weight heparin (LMWH) ameliorated colitis by undefined mechanisms in ulcerative colitis (UC) patients. Our study explored the mechanisms of LMWH on colitis from the perspective of gut microbiota and its metabolites.

2025-10-12 | MTBLS5770 | MetaboLights
TranscriptomicsIntegrative Molecular Concepts Modeling of Prostate Cancer Progression
Using laser capture microdissection to isolate over 100 specific cell populations, we report the profiling of prostate cancer progression from benign epithelium to metastatic disease. By analyzing these expression signatures in the context of over 15,000 â??molecular conceptsâ??, or sets of biologic...
ORGANISM(S): Homo sapiens 
2010-06-05 | E-GEOD-6099 | biostudies-arrayexpress
TranscriptomicsModeling Familial Cancer with iPSC Approaches
In vitro modeling of human disease has recently become feasible with the adoption of induced pluripotent stem cell (iPSC) technology. Here, we established patient-derived iPSCs from an Li-Fraumeni Syndrome (LFS) family and investigated the role of mutant p53 in the development of osteosarcoma (OS). ...
ORGANISM(S): Homo sapiens 
2015-04-10 | E-GEOD-58123 | biostudies-arrayexpress
TranscriptomicsOptimizing molecular signatures for prostate cancer recurrence
The derivation of molecular signatures indicative of disease status and predictive of subsequent behavior could facilitate the optimal choice of treatment for prostate cancer patients. In this study, we conducted a computational analysis of gene expression profile data obtained from 79 cases, 39 of ...
ORGANISM(S): Homo sapiens 
2010-11-05 | E-GEOD-25136 | biostudies-arrayexpress
UnknownMolecular modeling study of natural products as potential bioactive compounds against SARS-CoV-2.
Not available
S-EPMC10201022 | biostudies-literature
TranscriptomicsDose-response modeling of early molecular and cellular key events in CAR-mediated hepatocarcinogenesis pathway
Male and female CD-1 mice were administered dietary Phenobarbital for 2 or 7 days. In-life, enzyme activity, cell proliferation, genomic analysis, and Bench-mark dose modeling was carried out. The goal was to exmaine low-dose PB effects on early key events in CAR-mediated hepatocarcinogenesis. PB at...
ORGANISM(S): Mus musculus 
2014-02-01 | E-GEOD-54597 | biostudies-arrayexpress
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