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MetabolomicsPathogenic NLRP3 mutants form constitutively active inflammasomes resulting in immune-metabolic limitation of IL-1β production

BACKGROUND: Cryopyrin-Associated Periodic Syndrome (CAPS) is an autoinflammatory condition consequence of monoallelic variants in the NLRP3 gene that exacerbate IL-1β production. These variants are gain-of-function, but the exact regulatory mechanism of the NLRP3 CAPS-inflammasom...

2024-01-09 | MTBLS7872 | MetaboLights
TranscriptomicsComparison of miRNA profile in body fluids (plasma and bronchoalveolar fluid cytology)
The objective is to obtain miRNA representative signatures both in plasma and bronchoalveolar cell fraction that could serve as biomarker in respiratory diseases. The identification of new less invasive biomarkers is necessary to improve the detection and prognostic outcome of respiratory pathologic...
ORGANISM(S): Homo sapiens 
2011-10-20 | E-GEOD-33045 | biostudies-arrayexpress
UnknownEndophytic Microbes Are Tools to Increase Tolerance in Jasione Plants Against Arsenic Stress.
Not available
S-EPMC8527096 | biostudies-literature
UnknownLongitudinal Associations between Dietary Patterns and Weight Status in Puerto Rican Infants and Toddlers' Participants of the WIC Program.
Not available
S-EPMC9832917 | biostudies-literature
ProteomicsArsenic response of three altiplanic Exiguobacterium strains with different tolerance levels against the metalloid species: a proteomics study
In this work we compare the protein expression patterns of the three strains in response to arsenic by proteomic approach, strains were grown in absence of the metalloid and in presence of As(III) and As(V) sublethal concentrations and the protein separation was carried out in 2D electrophoresis gel...
ORGANISM(S): Exiguobacterium sp. SH31 
2019-10-23 | PXD014701 | Pride
Resistance Exiguobacterium 2-de Arsenic 
UnknownMultiple Mechanisms Driving F-actin-Dependent Transport of Organelles to and From Secretory Sites in Bovine Chromaffin Cells.
Not available
S-EPMC6190647 | biostudies-literature
UnknownMolecular characterization of the gene encoding a new AmpC beta-lactamase in a clinical strain of acinetobacter genomic species 3.
Not available
S-EPMC375293 | biostudies-literature
UnknownEffects of a pain oriented biobehavioral therapeutic education program on brain plasticity and pain intensity in subjects with chronic musculoskeletal pain: a feasibility study of a randomized controlled trial.
Not available
S-EPMC12665784 | biostudies-literature
UnknownManual Therapy Effects on Nonspecific Neck Pain Are Not Mediated by Mechanisms Related to Conditioned Pain Modulation: A Randomized Clinical Trial.
Not available
S-EPMC10298868 | biostudies-literature
UnknownEffect of Ischemia Duration and Protective Interventions on the Temporal Dynamics of Tissue Composition After Myocardial Infarction.
Not available
S-EPMC5542781 | biostudies-literature
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