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TranscriptomicsTranscription profiling of activated mixed glial (microglia) and monocyte-derived macrophages
Since macrophage activation can now be studied at a global level using modern microarray and proteomic analyses, discovery of novel macrophage activation genes is inevitable and important for understanding HIV-associated dementia (HAD). We isolated two different types of primary human macrophages, m...
ORGANISM(S): Homo sapiens 
2007-08-29 | E-GEOD-1910 | biostudies-arrayexpress
TranscriptomicsRNAseq of primary human monocyte derived macrophages (MDM) and differentiated THP-1 macrophages exposed to graphene-related (nano)materials (GRMs)
Occupational and consumer exposure to GRMs will increase but their impact on human health is still largely unknown. We sought to perform a transcriptome comparison of the bioresponses of MDM and THP-1 macrophages exposed to 5 or 20 µg/ml graphene oxide (GO) or graphene nanoplatelets (GNP) for 6 and ...
ORGANISM(S): Homo sapiens 
2023-02-01 | E-MTAB-10099 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human monocyte derived macrophages reveals induction of dendritic cell-like phenotype in macrophages during foam cell formation
Foam cell formation from monocyte-derived macrophages is a hallmark of atheroscle-rotic lesions. Aspects of this process can be recapitulated in vitro by exposing MCSF-induced or platelet factor4 (CXCL4)-induced macrophages to oxidized (ox) or minimally modified (mm) low density lipoprotein (LDL). W...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7138 | biostudies-arrayexpress
TranscriptomicsTranscriptional response of LPS-stimulated monocyte-derived macrophages in the presence or absence of the anti-TNF agonist Etanercept
We measured TNFα activity on the transcriptional level by identifying TNFα-inducible genes in human blood monocyte-derived macrophages (MDM). On the basis that TNFα does not act in isolation, we used bacterial lipopolysaccharide (LPS) as a prototypic model of a stimulus to invoke secretion of a w...
ORGANISM(S): Homo sapiens 
2017-08-04 | E-MTAB-5095 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human monocyte-derived macrophages infected in vitro with wild type Leishmania chagasi parasites and then cultured with naive, autologous T-cells
We performed gene expression analysis using Affymetrix U133Plus2 microarray chips on cultures of infected human cells. To mimic an in vivo infection, we infected human monocyte-derived macrophages (MDMs) in vitro with wild-type L. chagasi parasites and then co-cultured those infected MDMs with naiv...
ORGANISM(S): Homo sapiens 
2007-11-01 | E-MEXP-1290 | biostudies-arrayexpress
TranscriptomicsMacrophage Microvesicles Induce Macrophage Differentiation and miR-223 Transfer
Microvesicles (MV) are small membrane-bound particles comprised of exosomes and various sized extracellular vesicles. These are released by a number of cell types. Microvesicles have a variety of cellular functions from communication to mediating growth and differentiation. Microvesicles contain pro...
ORGANISM(S): Homo sapiens 
2013-03-08 | E-GEOD-41889 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human monocyte-derived macrophages infected with HIV-1 or uninfected and stimulated with E. coli lipopolysaccharide
Whole genome expression profiling of HIV-1 infected and uninfected monocyte-derived macrophages
ORGANISM(S): Homo sapiens 
2009-01-01 | E-MEXP-1904 | biostudies-arrayexpress
TranscriptomicsSimultaneous gene expression profiling in human macrophages infected with Leishmania major parasites using SAGE
Leishmania (L) are intracellular protozoan parasites which are able to survive and replicate within the harsh and potentially hostile phago-lysosomal environment of mammalian mononuclear phagocytes. A complex interplay then takes place between the macrophage (MM-NM-&) striving to eliminate the patho...
ORGANISM(S): Leishmania major 
2008-05-21 | E-GEOD-10442 | biostudies-arrayexpress
TranscriptomicsPan-genomic analysis of bovine monocyte-derived macrophage gene expression in response to in vitro infection with Mycobacterium avium subspecies paratuberculosis
Background: Mycobacterium avium subspecies paratuberculosis (MPTb) is the causative agent of Johne’s disease, an intestinal disease of ruminants with major economic consequences. MPTb bacilli are phagocytosed by host macrophages upon exposure where they persist, resulting in lengthy subclinical phas...
ORGANISM(S): Bos taurus 
2012-01-31 | E-GEOD-35185 | biostudies-arrayexpress
TranscriptomicsMonocyte-derived macrophages stimulated with the TLR8 agonist 3M-002 at 10 microM show a prominent activation of TLR-dependent genes as assessed b "Human Toll-like Receptor PCR array pathway" over time
We were interested in the effects of TLR8 triggering of human monocyte-derived macrophages. We observed a striking upregulation of those genes. This work was done in the context of examining the effects of TLR8 triggering for the activation of HIV. We generated monocyte-derived macrophages (MDM) by...
ORGANISM(S): Homo sapiens 
2011-01-11 | E-GEOD-26470 | biostudies-arrayexpress
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