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TranscriptomicsTranscription profiling of acute monocytic leukemia (AML-M5) patients with DNMT3A mutations
To understand the pathogenesis of DNMT3A in acute monocytic leukemia (AML-M5), we identified genes that are expressed differently in leukemia cells from AML-M5 patients collected at diagnosis with DNMT3A mutations (6 cases) compared to those without the mutations (4 cases). Differences of expression...
ORGANISM(S): Homo sapiens 
2011-02-12 | E-GEOD-27187 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of monocytic leukemia cell differentiation
The human leukemia cell line U937 is a well-established model for studying monocytic cell differentiation. We used a modified protocol (SADE) of serial analysis of gene expression (SAGE) and developed a SADE linker-anchored PCR assay to investigate the pattern of expression of known genes and to ide...
ORGANISM(S): Homo sapiens 
2004-10-23 | E-GEOD-1865 | biostudies-arrayexpress
GenomicsHomo sapiens strain:Human monocytic leukemia cells
Homo sapiens strain:Human monocytic leukemia cells Transcriptome or Gene expression
PRJNA902947 | ENA
TranscriptomicsTranscription profiling of human actute monocytic leukemia cell line THP-1 cells incubated at 37 or 32 degrees C for 24h reveals moderate hypothermia produces substantial changes in cellular gene expression, in categories potentially of importance to systemic function.
Background: Moderate hypothermia (32oC for 12 – 72 hours) has therapeutic applications, but the mechanisms by which it affects cellular function are unclear. We tested the hypothesis that moderate hypothermia produces broad changes in gene expression by human cells at the level of mRNA. Methods:...
ORGANISM(S): Homo sapiens 
2007-10-26 | E-GEOD-4425 | biostudies-arrayexpress
TranscriptomicsMicroarray profiling of monocytic differentiaion reveals miRNA-mRNA intrinsic correlation
This SuperSeries is composed of the following subset Series: GSE26376: Microarray profiling of monocytic differentiaion reveals miRNA-mRNA intrinsic correlation (miRNA) GSE26377: Microarray profiling of monocytic differentiaion reveals miRNA-mRNA intrinsic correlation (gene expression) Refer to indi...
ORGANISM(S): Homo sapiens 
2012-02-02 | E-GEOD-26379 | biostudies-arrayexpress
GenomicsShort-term time course of the effects of 1α,25-dihydroxyvitamin D3 treatment on open chromatin regions in THP-1 monocytic leukemia cells
Open chromatin regions have been shown to associate with the location of transcriptiotal enhancers, i.e., the binding locations of DNA-binding transcription factors. To investigate the effects of short-term treatment by the nuclear hormone 1α,25-dihydroxyvitamin D3 (VD), a specific ligand of the tr...
ORGANISM(S): Homo sapiens 
2012-10-25 | E-GEOD-40075 | biostudies-arrayexpress
ProteomicsCOVID-19-associated monocytic encephalitis (CAME): histological and proteomic evidence from autopsy
Severe neurological symptoms are associated with Coronavirus disease 2019 (COVID-19). However, the morphologic features, pathological nature and their potential mechanisms in patient brains have not been revealed despite evidence of neurotropic infection. In this study, neuropathological damages and...
ORGANISM(S): Homo Sapiens 
2022-12-12 | PXD038748 |
GenomicsSTRT RNAseq of THP-1 monocytic cells exposed to surface modified-gold nanoparticles
STRT RNAseq of THP-1 monocytic cells exposed to surface modified-gold nanoparticles
PRJEB28075 | ENA
TranscriptomicsIn vitro systems toxicology-based assessment of the potential modified risk tobacco product CHTP1.2 for vascular inflammation- and cytotoxicity-associated mechanisms promoting adhesion of monocytic cells to human coronary arterial endothelial cells.
Cigarette smoke causes diseases such as cardiovascular disorders. Heating tobacco, instead of burning, reduces consistently the amount of toxic compounds and may exert a reduced impact on cardiovascular health compared to cigarettes. Aqueous extract from the aerosol of a potential modified risk toba...
ORGANISM(S): Homo sapiens 
2018-08-09 | E-MTAB-6721 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human monocytic cells THP-1 stimulated with LPS (10ng/ml) in presence or absence of LL-37 (5 ug/ml), as well as with the peptide alone, for 4 hours
The objective of the study was to evaluate transcriptional response of endotoxin-stimulated human monocytic cells in presence or absence of host defense peptide LL-37 at low physiologically relevant concentrations. Human monocytic cells THP-1 were stimulated with LPS (10ng/ml) in presence or absenc...
ORGANISM(S): Homo sapiens 
2006-12-07 | E-FPMI-6 | biostudies-arrayexpress
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