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TranscriptomicsDifferential virulence gene expression in the pathogenic dermatophyte Arthroderma benhamiae in vitro versus infection
Although dermatophytes are the most common agents of superficial mycoses in humans and animals, the molecular basis of the pathogenicity of these fungi is largely unknown. In vitro digestion of keratin by dermatophytes is associated with the secretion of multiple proteases, which are assumed to be r...
ORGANISM(S): Arthroderma benhamiae 
2010-03-04 | E-GEOD-15873 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in the human pathogenic dermatophyte Trichophyton rubrum during growth on proteins
Dermatophytes are highly specialized filamentous fungi which cause the majority of superficial mycoses in humans and animals. The high secreted proteolytic activity of these microorganisms during growth on proteins is assumed to be linked with their particular ability to exclusively infect keratiniz...
ORGANISM(S): Trichophyton rubrum 
2008-12-30 | E-GEOD-11711 | biostudies-arrayexpress
ProteomicsThe adaptive metabolic response involves specific protein glutathionylation during the filamentation process in the pathogen Candida albicans
Candida albicans is an opportunist pathogen responsible for a large spectrum of infections, from superficial mycosis to the systemic disease candidiasis. Its ability to adopt various morphological forms, such as unicellular yeasts, filamentous pseudohyphae and hyphae, contributes to its ability to s...
ORGANISM(S): Candida albicans (Yeast) 
2016-04-21 | PXD003685 | Pride
Candida albicans / filamentation/ glutathionylation/ isocitrate lyase / mitochondria 
ProteomicsC. albicans cells exhibit specific proteomic profiles depending on the medium used to induce the filamentation process
Candida albicans is an opportunist pathogen responsible for a large spectrum of infections, from superficial mycosis to systemic diseases known as candidiasis. C. albicans can grow in various morphological forms, including unicellular budding yeasts, filamentous pseudophyphae and true hyphae, and th...
ORGANISM(S): Candida albicans (Yeast) 
2024-10-31 | PXD052475 | Pride
Candida albicans Metabolism Oxidative stress Proteomic Filamentation 
ProteomicsNovel insights into quantitative proteomics from an innovative bottom-up Simple Light Isotope Metabolic (bSLIM) labeling data processing strategy
The Simple Light Isotope Metabolic labeling (SLIM-labeling) is an inovative method to quantify proteome variations based on an original in vivo labeling strategy. Heterotrophic cells grown on a U-[12C] sole source of carbon synthesize U-[12C]-amino acids which are incorporated into proteins giving r...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-02-15 | PXD021329 | Pride
Openms Data processing workflow Yeast In vivo metabolic labeling Light carbon isotope Quantitative proteomics 12c Knime 
ProteomicsTraining set - Novel insights into quantitative proteomics from an innovative bottom-up Simple Light Isotope Metabolic (bSLIM) labeling data processing strategy
The Simple Light Isotope Metabolic labeling (SLIM-labeling) is an inovative method to quantify proteome variations based on an original in vivo labeling strategy. Heterotrophic cells grown on a U-[12C] sole source of carbon synthesize U-[12C]-amino acids which are incorporated into proteins giving r...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-02-16 | PXD021502 | Pride
Openms Data processing workflow Yeast In vivo metabolic labeling Light carbon isotope Quantitative proteomics 12c Knime 
ProteomicsThe metacaspase Mca1p restricts O-glycosylation during farnesol-induced apoptosis in Candida albicans
Protein glycolysation is an essential posttranslational modification in eukaryotic cells. In pathogenic yeasts, it is involved in a large number of biological processes, such as protein folding quality control, cell viability and host/pathogen relationships. A link between protein glycosylation and ...
ORGANISM(S): Candida albicans (Yeast) 
2016-05-02 | PXD003677 | Pride
Candida albicans O-glycosylation Glycoproteomics Ssb1 N-glycosylation Metacaspase Bgl2 Farnesol Glycomics Cdc48 Aminoxytmt Erad Pdi1 Orbitrap fusion. Apoptosis Glycans quantification 
UnknownThe metacaspase (Mca1p) has a dual role in farnesol-induced apoptosis in Candida albicans.
Not available
S-EPMC4288266 | biostudies-literature
ProteomicsIn vivo dynamics of Iron Starvation Induced Proteins under variable iron supplementation regimes suggest an iron processing organelle in Phaeodactylum tricornutum.
The model pennate diatom Phaeodactylum tricornutum is able to assimilate a range of iron sources. It therefore provides a platform to study different mechanisms of iron processing concomitantly in the same cell. In this study we follow the localisation of three iron starvation induced proteins (ISIP...
ORGANISM(S): Phaeodactylum tricornutum 
2023-03-10 | PXD021172 | Pride
Iron starvation induced proteins Fluorescent proteins Diatoms Siderophores Iron Proteome Phaeodactylum tricornutum 
ProteomicsImproved MS-based proteomics by the reduction of isotopic composition in vivo
Reducing the isotopic composition of proteins in vivo improves in-depth, high resolution MS-based quantitative proteomics. We used U-[12C]-glucose as the metabolic precursor of all amino acids in yeast. This substantially increased the peptide monoisotopic ion intensity in bottom-up analyses, greatl...
ORGANISM(S): Candida albicans (Yeast) 
2017-08-24 | PXD005364 | Pride
Protein half-life [u-12c]-carbon source Candida albicans Bottom-up ms-based proteomics 
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