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TranscriptomicsAffymetrix SNP array data for Genomic Instability and Myelodysplasia with Monosomy 7
Gene modified autologous hematopoietic stem cells (HSC) can provide significant clinical benefits to patients suffering from X-linked chronic granulomatous disease (X-CGD), a rare inherited immunodeficiency characterized by recurrent, often life threatening bacterial and fungal infections. Here we...
ORGANISM(S): Homo sapiens 
2010-01-12 | E-GEOD-19523 | biostudies-arrayexpress
ProteomicsProteomic analysis of human monosomic cell lines
Chromosome loss that results in monosomy has detrimental consequences for human cells, but the underlying molecular mechanisms remain enigmatic. Using p53 deficient monosomic cell lines, we found that chromosome loss impairs proliferation and genomic stability. Transcriptome and proteome analysis re...
ORGANISM(S): Homo sapiens (Human) 
2021-06-17 | PXD018440 | Pride
Tmt Monosomy Aneuploidy Lc-ms/ms 
TranscriptomicsMuscle transcriptome analysis of mouse models of partial trisomy and monosomy 21
Aneuploidies of human chromosome 21 (Down syndrome (DS) and monosomy 21 (M21)) lead to variable physiological abnormalities with constant mental retardation, locomotor deficits and altered muscle tone. To search for dosage-sensitive genes involved in DS and M21 phenotypes, we created two new mouse m...
ORGANISM(S): Mus musculus 
2015-12-31 | E-GEOD-58463 | biostudies-arrayexpress
TranscriptomicsIllumina GoldenGate Methylation array data for X-CGD patients and healthy controls
We report on the molecular and cellular events observed in two patients treated by gene therapy in 2004. After the initial resolution of bacterial and fungal infections, both patients exhibited silencing of transgene expression due to methylation of the viral promoter, and myelodysplasia with monoso...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-19515 | biostudies-arrayexpress
GenomicsAffymetrix SNP array data for adult Myelodysplastic Syndromes (MDS)/Acute Myeloid Leukemia (AML) with isolated monosomy 7
Affymetrix SNP array data for adult Myelodysplastic Syndromes (MDS)/Acute Myeloid Leukemia (AML) with isolated monosomy 7
PRJNA868755 | ENA
TranscriptomicsArray CGH with DNA extracted from Candida albicans strains and its derivatives, which is monosomic for chromosome 5
Goal of this experiment was to confirm the proposed monosomy condition of chromsome 5 genes in the derivatives Pair-wise comparison of genomic content between parental strains and their derivatives.
ORGANISM(S): Candida albicans 
2013-11-04 | E-GEOD-48093 | biostudies-arrayexpress
UnknownSystems approaches identify the consequences of monosomy in somatic human cells.
Not available
S-EPMC8458293 | biostudies-literature
TranscriptomicsGeneChip Mapping 500K set and Genome-Wide Human SNP 6.0 Array in meningioma tumors
Cytogenetic profiles of 50 meningiomas using high-density GeneChip Mapping 500K set and Genome-Wide Human SNP 6.0 Array in the tumor tissues and in the peripheral blood of the same patients. A total of two hundred 500k arrays (100 tumor samples and 100 blood samples) and 14 SNP6.0 arrays (7 tumour ...
ORGANISM(S): Homo sapiens 
2012-11-30 | E-GEOD-42624 | biostudies-arrayexpress
UnknownEpigenetic Dysregulation Observed in Monosomy Blastocysts Further Compromises Developmental Potential.
Not available
S-EPMC4896457 | biostudies-literature
UnknownUveal Melanoma Regression after Brachytherapy: Relationship with Chromosome 3 Monosomy Status.
Not available
S-EPMC5567042 | biostudies-literature
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