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MetabolomicsMetabolic Effects of a Chronic Dietary Exposure to a Low-Dose Pesticide Cocktail in Mice: Sexual Dimorphism and Role of the Constitutive Androstane Receptor (Untargeted urine UPLC-MS assay)
BACKGROUND: Epidemiological evidence suggests a link between pesticide exposure and the development of metabolic diseases. However, most experimental studies have evaluated the metabolic effects of pesticides using individual molecules, often at non relevant doses or in combination with other r...
2019-05-28 | MTBLS596 | MetaboLights
TranscriptomicsGlobal hepatic gene expression data from germ free and specific pathogen free male mice.
Liver clock regulates transcription of hepatic genes in response to feeding. To explore the possibility that the microbiome influences this process, we measured the liver transcriptome in normal mice (Specific Pathogen Free or SPF mice) and compared it to the transcriptome in mice lacking microbiota...
ORGANISM(S): Mus musculus 
2016-02-20 | E-GEOD-71628 | biostudies-arrayexpress
TranscriptomicsGlobal hepatic gene expression data from PPARa liver KO, PPARa liver WT, PPARaKO and WT male mice fed ad libitum, fasted for 24 hours and re-fed
If the function of the nuclear receptor PPARa is well-known during a prolongated fasting, its hepatic biological function during feeding and refeeding conditions still needs to be investigated. Moreover, in vivo data collected so far on PPARa function during fasting were obtained using the total Ppa...
ORGANISM(S): Mus musculus 
2016-02-20 | E-GEOD-73299 | biostudies-arrayexpress
TranscriptomicsGlobal hepatic gene expression data from PPARa liver KO, PPARa liver WT, PPARaKO and WT male mice treated or not with Fenofibrate
Fenofibrate is a specific agonist of the nuclear receptor PPARa. To identify the gene expression under the strict dependence of hepatic PPARa activity, we generated a new mouse strain of PPARa-specific deletion in hepatocyte (albumin-Cre+/- Pparaflox/flox or LKO) and we compared them to total Ppara ...
ORGANISM(S): Mus musculus 
2016-02-20 | E-GEOD-73298 | biostudies-arrayexpress
UnknownHepatic FGF21 is not required for fasting metabolism but guides protein appetite post energy depletion
Not available
S-SCDT-10_1038-S44319-026-00790-9 | biostudies-other
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