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UnknownAcute maternal oxidant exposure causes susceptibility of the fetal brain to inflammation and oxidative stress.

Background

Maternal exposure to environmental stressors poses a risk to fetal development. Oxidative stress (OS), microglia activation, and inflammation are three tightly linked mechanisms that emerge as a causal factor of neurodevelopmental anomalies associated with prenatal ethanol exposur...
S-EPMC5622443 | biostudies-literature
UnknownProteomic and metagenomic insights into prehistoric Spanish Levantine Rock Art.
The Iberian Mediterranean Basin is home to one of the largest groups of prehistoric rock art sites in Europe. Despite the cultural relevance of prehistoric Spanish Levantine rock art, pigment composition remains partially unknown, and the nature of the binders used for painting has yet to be disclos...
S-EPMC6030215 | biostudies-literature
UnknownA Culturally Targeted eLearning Module on Organ Donation (Promotoras de Donacion): Design and Development.

Background

As an overrepresented population on the transplant waitlist, stagnated rates of organ donation registration among Latinxs must be redressed. Promotoras (community health workers), who are effective at advocating and spearheading health promotion efforts in the Latinx community, sh...
S-EPMC6996759 | biostudies-literature
UnknownCerebral Cortical Encephalitis in Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease.
Cerebral cortical encephalitis (CCE) is a recently described myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) phenotype. In this observational retrospective study, we characterized 19 CCE patients (6.7% of our MOGAD cohort). Headache (n = 15, 79%), seizures (n = 13, 68%), and ...
S-EPMC10107670 | biostudies-literature
UnknownComparison in the adult congenital heart disease severity classification of ACC/AHA and ESC guidelines in a 3,459 Mexican population.

Background

Latin American registries of clinical and demographic profiles of ACHD are scarce. International guidelines classify disease complexity with different approaches. With these two regards, a registry was carried out to examine factors associated with mortality and to compare severit...
S-EPMC11657258 | biostudies-literature
UnknownMapping DNA Methylation Signatures to Identify Epigenetic Variation Across Subcortical Regions of the Human Posttraumatic Stress Disorder Brain.

Background

Posttraumatic stress disorder (PTSD) is a mental disorder that may occur in the aftermath of severe psychological trauma. Epigenetic changes in the brain may play a critical role in understanding the neurobiology of PTSD by linking environmental traumatic stress exposure to lastin...
S-EPMC12862789 | biostudies-literature
UnknownDevelopment and Validation of an Early Mortality Risk Score for Older Patients Treated with Chemotherapy for Cancer.
Background: Estimation of life expectancy in older patients is relevant to select the best treatment strategy. We aimed to develop and validate a score to predict early mortality in older patients with cancer. Patients and Methods: A total of 749 patients over 70 years starting new chemotherapy regi...
S-EPMC8070509 | biostudies-literature
UnknownFecal immunochemical test accuracy in average-risk colorectal cancer screening.

Aim

To assess the fecal immunochemical test (FIT) accuracy for colorectal cancer (CRC) and advanced neoplasia (AN) detection in CRC screening.

Methods

We performed a multicentric, prospective, double blind study of diagnostic tests on asymptomatic average-risk individuals submitted to...
S-EPMC3921527 | biostudies-literature
TranscriptomicsExpression data from human Wharton's jelly stem cells
Human umbilical cord Wharton’s jelly stem cells (WHJSC) are gaining attention as a possible clinical source of mesenchymal stem cells for use in cell therapy and tissue engineering due to their high accessibility, expansion potential and plasticity. However, the cell viability changes that are assoc...
ORGANISM(S): Homo sapiens 
2011-07-06 | E-GEOD-30391 | biostudies-arrayexpress
UnknownEffect of Intrawound Vancomycin Powder in Operatively Treated High-risk Tibia Fractures: A Randomized Clinical Trial.

Importance

Despite the widespread use of systemic antibiotics to prevent infections in surgically treated patients with fracture, high rates of surgical site infection persist.

Objective

To examine the effect of intrawound vancomycin powder in reducing deep surgical site infections.
S-EPMC12285540 | biostudies-literature
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