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ProteomicsChronic stress alters the E/I balance of pyramidal neurons in the infralimbic and Prelimbic cortices
The medial prefrontal cortex (mPFC) is a key brain region involved in controlling working memory, executive function, and self-regulatory behaviours, and its malfunction is a hallmark of several neuropsychiatric disorders such as schizophrenia, depression, and post-traumatic stress disorder. One of ...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD047291 | Pride
Infralimbic cortex Chronic stress Prelimbic cortex E/i balance 
ProteomicsChronic stress causes striatal disinhibition mediated by SOM-interneurons
Chronic stress is a major triggering factor for neuropsychiatric disorders including obsessive-compulsive disorder (OCD), a mental health condition characterized by motor stereotypies and striatal overactivation. However, the mechanisms at the cell- and microcircuit-level through which stress trigge...
ORGANISM(S): Mus musculus (Mouse) 
2022-12-13 | PXD031193 | Pride
Striatum Swath-ms Chronic stress 
ProteomicsChronic haloperidol treatment leads to an imbalance of synaptic excitation and inhibition of D1-MSN neurons pointing to a slow remodelling process
Schizophrenia is a chronic mental illness that is among the world’s top twenty causes of years lost to disability according to the global burden of disease 2019 (10.1016/S0140-6736(20)30925-9). Positive symptoms, including hallucinations and delusions in schizophrenia, often improved with convention...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-24 | PXD038471 | Pride
Msn Haloperidol Proteomics 
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Not available
S-EPMC12706683 | biostudies-literature
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S-EPMC8302820 | biostudies-literature
UnknownGuidance on mucositis assessment from the MASCC Mucositis Study Group and ISOO: an international Delphi study.
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S-EPMC11200283 | biostudies-literature
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S-EPMC10251070 | biostudies-literature
UnknownExtended pharmacological thromboprophylaxis and clinically relevant venous thromboembolism after major abdominal and pelvic surgery: international, prospective, propensity score-weighted cohort study.
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S-EPMC11894929 | biostudies-literature
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S-EPMC9621702 | biostudies-literature
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