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ProteomicsCRISPR targeting of FOXL2 c.402C>G mutation reduces malignant phenotype in granulosa tumor cells and identifies anti-tumoral compounds
FOXL2 is a transcription factor that plays a key role in sex determination, ovary development and maintenance. Mutations related to this gene have been described in syndromes involving premature ovarian failure and granulosa cell tumors. This kind of rare cancer (less than 5% of diagnosed ovarian ca...
ORGANISM(S): Homo sapiens (Human) 
2025-03-15 | PXD053682 | Pride
Tmt Rare cancer Crispr Granulosa cell tumor Proteomics Foxl2 
ProteomicsCB2R loss drives trastuzumab resistance by reorganizing HER2 dimers to evade IFN-γ and enhance EGFR signaling
Despite advances in HER2+ breast cancer treatment, resistance to anti-HER2 therapies remains a significant clinical challenge. This study investigated the role of the endocannabinoid system, specifically the HER2-CB2R heterodimer, in trastuzumab resistance mechanisms. Analysis of human breast cancer...
ORGANISM(S): Homo sapiens (Human) 
2026-05-07 | PXD065700 | Pride
Breast cancer Immunoprecipitation Proteomics Her2 Cb2r 
ProteomicsBenefits of FAIMS to improve the proteome coverage of hard-to-analyze TMT 10-plex FFPE tissue and plasma-derived exosomes samples
The analysis of complex protein mixtures, such as FFPE tissue or plasma exosomes samples, is a challenge nowadays due to the low proteome coverage achieved by mass spectrometers nowadays. We have here investigated the benefits of FAIMS technology coupled to the Orbitrap Exploris 480 mass spectromete...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD042601 | Pride
Orbitrap exploris 480 Mass spectrometry Proteomics Faims Ffpe tissue Exosomes 
ProteomicsBenefits of FAIMS to improve the proteome coverage of deteriorated, and/or cross-linked TMT 10-plex FFPE tissue and plas-ma-derived exosomes samples
The analysis of complex protein mixtures, such as FFPE tissue or plasma exosomes samples, is a challenge nowadays due to the low proteome coverage achieved by mass spectrometers nowadays. We have here investigated the benefits of FAIMS technology coupled to the Orbitrap Exploris 480 mass spectromete...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD045367 | Pride
Orbitrap exploris 480 Mass spectrometry Proteomics Faims Ffpe tissue Exosomes 
ProteomicsBenefits of FAIMS to improve the proteome coverage of deteri-orated, and/or cross-linked TMT 10-plex FFPE tissue and plas-ma-derived exosomes samples
The analysis of complex protein mixtures, such as FFPE tissue or plasma exosomes samples, is a challenge nowadays due to the low proteome coverage achieved by mass spectrometers nowadays. We have here investigated the benefits of FAIMS technology coupled to the Orbitrap Exploris 480 mass spectromete...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD045362 | Pride
Orbitrap exploris 480 Mass spectrometry Proteomics Faims Ffpe tissue Exosomes 
ProteomicsBenefits of FAIMS to improve the proteome coverage of hard-to-analyze TMT 10-plex FFPE tissue and plasma-derived exosomes samples
The analysis of complex protein mixtures, such as FFPE tissue or plasma exosomes samples, is a challenge nowadays due to the low proteome coverage achieved by mass spectrometers nowadays. We have here investigated the benefits of FAIMS technology coupled to the Orbitrap Exploris 480 mass spectromete...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD042596 | Pride
Orbitrap exploris 480 Mass spectrometry Proteomics Faims Ffpe tissue Exosomes 
ProteomicsBenefits of FAIMS to improve the proteome coverage of hard-to-analyze TMT 10-plex FFPE tissue and plasma-derived exosomes samples
The analysis of complex protein mixtures, such as FFPE tissue or plasma exosomes samples, is a challenge nowadays due to the low proteome coverage achieved by mass spectrometers nowadays. We have here investigated the benefits of FAIMS technology coupled to the Orbitrap Exploris 480 mass spectromete...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD042597 | Pride
Orbitrap exploris 480 Mass spectrometry Proteomics Faims Ffpe tissue Exosomes 
ProteomicsProteomics analyses of small extracellular vesicles of aqueous humor: identification and validation of GAS6 and SPP1 as glaucoma markers during cataracts surgery
A high percentage of vision loss and blindness worldwide are due to glaucoma and cataracts ocular diseases. Small extracellular vesicles (sEVs) are small lipidic vesicles involved in transport and cell-to-cell communication, released into different body fluids including eye’s aqueous humor. The iden...
ORGANISM(S): Homo sapiens (Human) 
2024-11-04 | PXD048815 | Pride
Glaucoma diagnosis Proteomics Aqueous humor Glaucoma Small extracellular vesicles Elisa Cataracts 
ProteomicsFunctional proteomics characterization of the role of SPRYD7 in colorectal cancer progression and metastasis
SPRY domain-containing protein 7 (SPRYD7) is a barely known protein identified by spatial proteomics as upregulated in highly-metastatic to liver KM12SM colorectal cancer (CRC) cells in comparison to its isogenic poorly-metastatic KM12C CRC cells. Here, we aimed at analyzing SPRYD7 role in CRC by fu...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD042874 | Pride
Colorectal cancer  spryd7  cancer metastasis  proteomics  protein dysregulation  interactome 
ProteomicsFunctional proteomics characterization of the role of SPRYD7 in colorectal cancer progression and metastasis
SPRY domain-containing protein 7 (SPRYD7) is a barely known protein identified by spatial proteomics as upregulated in highly-metastatic to liver KM12SM colorectal cancer (CRC) cells in comparison to its isogenic poorly-metastatic KM12C CRC cells. Here, we aimed at analyzing SPRYD7 role in CRC by fu...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD042901 | Pride
Colorectal cancer  spryd7  cancer metastasis  proteomics  protein dysregulation  interactome 
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