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Transcriptomicsmut-16 and other mutator-class genes modulate 22G and 26G siRNA pathways in Caenorhabditis elegans
Argonaute-associated siRNAs and Piwi-associated piRNAs have overlapping roles in silencing mobile genetic elements in animals. In C. elegans, mutator-class (mut) genes mediate siRNA-guided repression of transposons as well as exogenous RNA-directed gene silencing (RNAi), but their roles in endogeno...
ORGANISM(S): Caenorhabditis elegans 
2011-02-01 | E-GEOD-26165 | biostudies-arrayexpress
ProteomicsProtein-protein interactions of DRSH-1 and PASH-1 in C. elegans
A mass spectrometry-based proteomics analysis was performed to study the protein binders of DRSH-1 and PASH-1 in C. elegans.
ORGANISM(S): Escherichia coli Caenorhabditis elegans 
2025-03-13 | PXD052084 | Pride
C. elegans Drsh-1 Protein-protein interactions Pash-1 
TranscriptomicsAGO1-dependent Small RNA in Arabidopsis Identified by High-Throughput Sequencing
The goal of this study was to identify AGO1-dependent miRNA and tasiRNA in Arabidopsis by sequencing small RNA from wild type (Col-0) and ago1-25 plants. Keywords: Small RNA Sequencing-by-synthesis technology was used to sequence small RNA from flower tissue (stages 1-12) from wild-type (Col-0) and...
ORGANISM(S): Arabidopsis thaliana 
2008-11-17 | E-GEOD-13605 | biostudies-arrayexpress
TranscriptomicsThe Caenorhabditis elegans RDE-10/RDE-11 complex regulates RNAi by promoting secondary siRNA amplification
From a forward genetic screen for C. elegans genes required for RNAi, we identified rde-10 and through proteomic analysis of RDE-10-interacting proteins, we identified a protein complex containing the new RNAi factor RDE-11, the known RNAi factors RSD-2 and ERGO-1, as well as other candidate RNAi fa...
ORGANISM(S): Caenorhabditis elegans 
2012-04-07 | E-GEOD-37083 | biostudies-arrayexpress
TranscriptomicsThe ERI-6/7 helicase acts at the first stage of an siRNA amplification pathway that targets recent gene duplications.
To characterize the role of the ERI-6/7 helicase in endogenous small RNA pathways in C. elegans, small RNA populations from null alleles of eri-6 and eri-7, and from mutants of known endogenous RNAi pathway factors, eri-1 and ergo-1, were determined by deep sequencing, and compared to wild type. Sma...
ORGANISM(S): Caenorhabditis elegans 
2011-09-25 | E-GEOD-32366 | biostudies-arrayexpress
TranscriptomicsFunctional analysis of Arabidopsis ARGONAUTE1 using a slicer-defective mutant: Small RNA immunoprecipitation
The Arabidopsis ARGONAUTE (AGO) protein AGO1 associates with microRNA (miRNA) and specific classes of short-interfering RNA (siRNA). AGO1-small RNA complexes recognize target RNA transcripts through base-pairing interactions and inhibit translation of target RNAs through endonucleolytic cleavage (sl...
ORGANISM(S): Arabidopsis thaliana 
2012-09-28 | E-GEOD-40258 | biostudies-arrayexpress
TranscriptomicsFunctional analysis of Arabidopsis ARGONAUTE1 using a slicer-defective mutant: Transcript immunoprecipitation
The Arabidopsis ARGONAUTE (AGO) protein AGO1 associates with microRNA (miRNA) and specific classes of short-interfering RNA (siRNA). AGO1-small RNA complexes recognize target RNA transcripts through base-pairing interactions and inhibit translation of target RNAs through endonucleolytic cleavage (sl...
ORGANISM(S): Arabidopsis thaliana 
2012-09-28 | E-GEOD-40256 | biostudies-arrayexpress
TranscriptomicsGlobal identification of Arabidopsis thaliana ARGONAUTE1-associated small RNA.
Small RNA from total RNA (input fraction) and immunoprecipitated HA-AGO1-complexes (IP fraction) were identified using high-throughput sequencing-by-synthesis. Two replicate input fraction samples were used as controls for two replicate IP fraction samples. Total RNA from input fractions and small R...
ORGANISM(S): Arabidopsis thaliana 
2010-06-21 | E-GEOD-22252 | biostudies-arrayexpress
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