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A mass spectrometry-based proteomics analysis was performed to study the protein binders of DRSH-1 and PASH-1 in C. elegans.
ORGANISM(S): Escherichia coli Caenorhabditis elegans 
2025-03-13 | PXD052084 | Pride
Regulation of gene expression by microRNAs (miRNAs) is essential for normal development, but the roles of miRNAs in the physiology of adult animals are poorly understood. We have isolated a conditional allele of DGCR8/pash-1, which allows reversible and rapid inactivation of miRNA synthesis in vivo ...
ORGANISM(S): Caenorhabditis elegans 
Genomics
Small RNAseq of Pristionchus pacificus pash-1(Pasha/DGCRR8) mutant
Genomics
Protective role of PASH-1 in CGG repeat-driven RNA and protein toxicity in FXTAS
Protective role of PASH-1 in CGG repeat-driven RNA and protein toxicity in FXTAS
Primary microRNA (pri-miRNA) transcripts are processed by a protein complex called the Microprocessor comprised of the ribonuclease Drosha and its RNA binding partner DGCR8/Pasha. We sequenced small RNAs from animals containing a mutation in the WW domain of C. elegans pash-1. We found that these mu...
ORGANISM(S): Caenorhabditis elegans 
2024-04-16 | GSE263914 | GEO
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