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ProteomicsA multidisciplinary integrated approach for the identification and characterization of the AMP profile in Hermetia illucens hemolymph
The growing threat of antimicrobial resistance calls for alternative strategies to conventional antibiotics. Insects represent a promising source of antimicrobial peptides (AMPs) due to their potent innate immune responses. In this study, we investigated the peptide extracts from hemolymph of Hermet...
ORGANISM(S): Hermetia illucens 
2026-06-01 | PXD071144 | Pride
Antimicrobial peptides  hermetia illucens  antimicrobial resistance  proteomics  in vitro antibacterial assay  in silico prediction 
TranscriptomicsGene expression profiling of two diffuse large B-cell lymphoma (DLBCL) cell lines, DHL4 and DHL6, treated with the SYK inhibitor, R406
The two DLBCL cell lines were treated with R406 to assess the signature of SYK inhibition. In previous studies, R406 decreased the proliferation and induced apoptosis of these surface Ig+ cell lines. In the previous studies, R406 inhibited the autophosphorylation of SYK 525/526 and SYK-dependent pho...
ORGANISM(S): Homo sapiens 
2013-12-31 | E-GEOD-34176 | biostudies-arrayexpress
UnknownRSPO1-mutated keratinocytes from palmoplantar keratoderma display impaired differentiation, alteration of cell-cell adhesion, EMT-like phenotype and invasiveness properties: implications for squamous cell carcinoma susceptibility in patients with 46XX disorder of sexual development.
Not available
S-EPMC9295301 | biostudies-literature
TranscriptomicsTranscription profiling of human skin biopsies in cutaneous T-cell lymphoma
Cutaneous T cell lymphoma (CTCL) is defined by infiltration of activated and malignant T cells in skin. The clinical manifestations and prognosis in CTCL are highly variable. In this study, we hypothesized that gene expression analysis in lesional skin biopsies can improve understanding of the disea...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-9479 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of five diffuse large B-cell lymphoma (DLBCL) cell lines, DHL4, DHL6, LY7, HBL1 and U2932, treated with the SYK inhibitor, R406
The five DLBCL cell lines were treated with R406 to assess the signature of SYK inhibition. In previous studies, R406 decreased the proliferation and induced apoptosis of these surface Ig+ cell lines. In the previous studies, R406 inhibited the autophosphorylation of SYK 525/526 and SYK-dependent ph...
ORGANISM(S): Homo sapiens 
2013-08-31 | E-GEOD-43510 | biostudies-arrayexpress
TranscriptomicsA YAP/TAZ-Regulated Molecular Signature is Associated with Oral Squamous Cell Carcinoma
Oral squamous cell carcinoma (OSCC) is a prevalent form of cancer that develops from the epithelium of the oral cavity. OSCC is on the rise worldwide, and death rates associated with the disease are particularly high. Despite progress in understanding of the mutational and expression landscape assoc...
ORGANISM(S): Homo sapiens 
2015-05-26 | E-GEOD-66949 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human primary epithelial nasal cells infected with SARS-CoV-2 (20A clade) and treated with long chain inorganic polyphosphates (polyP120) against vehicle-(saline solution)- treated controls
Primary human nasal epithelial cells collected by nasal brushing of healthy donors (data deposited at: EVA- EMBL-EBI; project ID: PRJEB42411; analyses: ERZ1700617) were plated (3x105 cells) and infected with SARS-CoV-2 viral particles 20A (EPI_ISL_514432-S66; MOI, 0.03). After 24 hours, the infected...
ORGANISM(S): Homo sapiens 
2024-05-31 | E-MTAB-13363 | biostudies-arrayexpress
UnknownClinical predictors of late SARS-CoV-2 positivity in Italian internal medicine wards.
Not available
S-EPMC8646747 | biostudies-literature
UnknownDerivation and validation of four patient clusters in Still's disease, results from GIRRCS AOSD-study group and AIDA Network Still Disease Registry.
Not available
S-EPMC10660445 | biostudies-literature
TranscriptomicsTargeting ATP2B1 impairs PI3K/Akt/Forkhead box (Fox) transcription factor signaling and reduces SARS-COV-2 infection and replication
RNA-seq of human cells Edited using CRISPR vs parental and Unedited control. We identified a rare homozygous intronic variant in the ATP2B1 locus (rs111337717; chr12:89643729, T>C) that is associated with the severity of COVID-19 (i.e., symptomatic versus asymptomatic patients). Next, we employed ...
ORGANISM(S): Homo sapiens 
2024-05-13 | E-MTAB-13916 | biostudies-arrayexpress
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