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TranscriptomicsIdentification of novel genes associated with human glioblastoma (GBM) tumor-initiating cells (TICs)
Most patients affected by Glioblastoma multiforme (GBM) experience a recurrence of the disease because of the spreading of tumor-initiating cells (TICs) beyond surgical boundary. Unveiling and targeting molecular mechanisms causing this process is a logic goal to impair GBM killing ability. In an or...
ORGANISM(S): Homo sapiens 
2012-09-11 | E-GEOD-16805 | biostudies-arrayexpress
TranscriptomicsGenechip analysis of bone marrow osteoprogenitors exposed to microgravity
In March 2006, murine Bone Marrow Stromal Cells (BMSC) were flown in the Soyuz 12S to the International Space Station to investigate the effects of microgravity on their osteogenic potential in a three-dimensional environment. BMSC were grown in porous bioceramic Skelite disks (Φ 9 mm x T 1.2 mm). ...
ORGANISM(S): Mus musculus 
2010-10-15 | E-GEOD-17696 | biostudies-arrayexpress
TranscriptomicsGene expression profiling by DNA microarray in Colo741 cell line transfected by KRas-G12D or KRas-G12V
Mutations of the proto-oncogene KRas, together with the inactivation of the onco-suppressor genes APC and TP53, are considered to have an important role both in the carcinogenesis and in the colorectal tumor progression. The oncogene K-ras has activating mutations, especially in codon 12, in about ...
ORGANISM(S): Homo sapiens 
2008-12-17 | E-GEOD-12398 | biostudies-arrayexpress
TranscriptomicsThe gamma secretase inhibitor LLNle induces apoptosis of human GBM tumor initiating cells
Glioblastomas (GBM) are poorly differentiated astrocytic tumors arising in the Central Nervous System (CNS), which despite aggressive treatments are still characterized by a fatal outcome. Several studies have shown the existence of a subpopulation of cells within glioma tumors displaying cancer ste...
ORGANISM(S): Homo sapiens 
2010-04-09 | E-GEOD-14581 | biostudies-arrayexpress
TranscriptomicsNAC, Tiron and Trolox impair GBM tumorigenic cell survival by mechanisms independent from antioxidant activity
The aim of this study is to determine if, using antioxidant drugs, it is possible to interfere with the proliferative capabilities of the human glioblastoma (GBM) tumor-initiating cells (TICs). To establish which cellular processes are activated in GBM TICs by the antioxidants NAC, Tiron and Trolox,...
ORGANISM(S): Homo sapiens 
2014-03-04 | E-GEOD-44099 | biostudies-arrayexpress
TranscriptomicsDemethyl fructiculin A (SCO-1) induces apoptosis by inducing reactive oxygen species in mitochondria
Demethyl fructiculin A is a diterpenoid quinone component of the exudates from Salvia corrugata (SCO-1) leafes. SCO-1 was recently reported to induce anoikis in mammalian cell lines via a molecular mechanism involving the presence of the membrane scavenging receptor CD36. However, experiments perfor...
ORGANISM(S): Homo sapiens 
2010-10-15 | E-GEOD-19846 | biostudies-arrayexpress
TranscriptomicsGenomic DNA damage in oral potentially malignant disorders (OPMDs) and oral squamous cell carcinomas (OSCCs). Early detection of DNA aneuploidy and chromosomal aberrations in non dysplastic OPMDs.
Oral potentially malignant disorders (OPMDs) may precede oral squamous cell carcinoma (OSCC). Early detection of OPMDs has a crucial role in OSCC prevention. DNA aneuploidy and chromosomal aberrations are markers of genomic DNA damage and chromosomal instability (CIN), which is involved in cancer d...
ORGANISM(S): Homo sapiens 
2015-10-23 | E-GEOD-66136 | biostudies-arrayexpress
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