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TranscriptomicsTranscription profiling of mouse cystic fibrosis model Cftr knockouts ileum were analysed to investigate intestinal phenotypes
Cystic fibrosis transmembrane conductance regulator (Cftr) knockout mice present the clinical features of low body weight and intestinal disease permitting an assessment of the interrelatedness of these phenotypes in a controlled environment. To identify intestinal alterations which affect body wei...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-5715 | biostudies-arrayexpress
TranscriptomicsTranscriptional Profiling of rat hypothalamic response to TCDD
In many mammals, halogenated aromatic hydrocarbon (HAH) exposure causes wasting syndrome, defined as lethal weight loss as a result of severe and persistent hypophagia. The most potent HAH in causing wasting is 2,3,7,8-tetrachlorodibenzo-ρ-dioxin (TCDD), which exerts its toxic effects through the ar...
ORGANISM(S): Rattus norvegicus 
2014-12-23 | E-GEOD-61039 | biostudies-arrayexpress
ProteomicsGut Microbial Ecosystem Multiomics in Inflammatory Bowel Disease
Using multiple omics approaches to explore the effect of the gut microbial ecosytem on inflammatory bowel disease
ORGANISM(S): Environmental Samples <bacteria> (ncbitaxon:48479) 
2019-07-02 | MSV000084050 | MassIVE
TranscriptomicsMyeloid derived suppressor cells enhance stemness of cancer cells by inducing miRNA101 and suppressing the corepressor CtBP2
The work identifies an immune associated cellular, molecular and clinical network involving MDSCs-microRNA101-CtBP2-stem cell core genes, which extrinsically controls cancer stemness and impacts patient outcome. Primary ovarian cancer cells (5 x105) were co-cultured with freshly sorted ovarian cance...
ORGANISM(S): Homo sapiens 
2013-08-23 | E-GEOD-50082 | biostudies-arrayexpress
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