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ProteomicsEarly retinal synaptic dysfunction and proteomic remodeling precede neurodegeneration in a Parkinson’s disease model
Parkinson’s disease (PD) affects motor and non-motor systems, but retinal changes and their molecular basis are not well understood. Using a transgenic mouse model overexpressing A53T-mutant human α-synuclein, we examined retinal function, structure, and proteomics at 6 and 16 months. Early retinal ...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-23 | PXD066087 | Pride
Visual dysfunction Retina Parkinson's disease Proteomics 
ProteomicsProteomic Analysis of Full-Thickness Rotator Cuff Tears: Potential Role of Tetranectin in Synovial Fluid
Rotator cuff tears are one of the most common shoulder disorders and can lead to pain, weakness, and limited mobility. Although the clinical condition has been widely studied, its molecular mechanisms are still not fully understood. In this study, we analyzed the proteomic profile of synovial fluid ...
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD064264 | Pride
Full-thickness rotator cuff tears Synovial fluid Proteomics Tetranectin 
ProteomicsProteomic Analysis of Retina-derived CD29 positive Müller Cells in a Myopia induced rabbit model
The prevalence of myopia is rapidly increasing, significantly impacting the quality of life for affected individuals. Prior research in our group observed reactive gliosis in Müller cells within myopia-induced retinas, prompting further investigation into their role in myopia. In this study, we anal...
ORGANISM(S): Oryctolagus cuniculus (Rabbit) 
2025-05-07 | PXD053804 | Pride
Myopia Müller cells Proteomics Oxidative stress Glycolysis 
ProteomicsRetinal proteome analysis reveals region-specific change in the rabbit myopia model
Uncovering region-specific change in myopic retina can provide the clue for explaining the pathogenesis of myopia progression. After imposing form deprivation myopia (FDM) on the right eye of 6-week-old rabbits, we investigated the proteome profile of each retinal region (central, mid periphery, an...
ORGANISM(S): Oryctolagus cuniculus (Rabbit) 
2023-03-10 | PXD038552 | Pride
Retina Rabbit Myopia Lc-ms/ms 
ProteomicsAmplified fluorogenic immunoassay for early diagnosis and monitoring of Alzheimer’s disease from tear fluid
Accurate diagnosis of Alzheimer’s disease (AD) in its earliest stage can prevent the disease and delay the onset of symptoms by maintaining a healthy lifestyle and controlling modifiable risk factors. Therefore, more sensitive, relatively inexpensive, non-invasive, and simple screening tools are req...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD042142 | Pride
Alzheimer’s disease Immunoassay Magnetic nanoparticles Polymeric nanoprobes Tear fluid 
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