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MetabolomicsBacteroides uniformis-Induced Gut Dysbiosis Promotes High Myopia Progression via Pyroglutamic Acid

Plasma samples from subjects with high myopia and those with normal visual acuity were collected for untargeted metabolomic analysis, with the aim of identifying differential plasma metabolites.

2025-11-22 | MTBLS13369 | MetaboLights
TranscriptomicsTranscription profiling of chicken with experimentally induced myopia
One-day old white Leghorn chicks were housed in brooders with a 12 hr light:dark cycle, using General Electric chroma 50 fluorescent lighting with irradiance of approximately 50μW/cm2 at chick eye level. They received Purina Chick Chow food and water ad libitum. At one week of age and at the onset ...
ORGANISM(S): Gallus gallus 
2008-11-08 | E-GEOD-6543 | biostudies-arrayexpress
TranscriptomicsForm deprivation modulates retinal neurogenesis in primate experimental myopia
Juvenile primates develop myopia when their visual experience is degraded by lid fusion. In response to the abnormal visual input, retinal neural networks cause an excessive growth of the postequatorial segment of the eye, but the mechanism underlying this axial elongation is unknown. By combining a...
ORGANISM(S): Macaca mulatta 
2010-07-01 | E-GEOD-3300 | biostudies-arrayexpress
ProteomicsHuman corneal stroma proteomic profile of myopic eyes
This is a cross-sectional case-control study. Study subjects of generalized myopic patients in preparation for small incision lenticule extraction (SMILE) surgery were recruited and divided into low and high myopia subgroups.
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD025145 | Pride
Human Lc-ms/ms Cornea Myopia Stroma Proteome 
ProteomicsRetinal proteome analysis reveals region-specific change in the rabbit myopia model
Uncovering region-specific change in myopic retina can provide the clue for explaining the pathogenesis of myopia progression. After imposing form deprivation myopia (FDM) on the right eye of 6-week-old rabbits, we investigated the proteome profile of each retinal region (central, mid periphery, an...
ORGANISM(S): Oryctolagus cuniculus (Rabbit) 
2023-03-10 | PXD038552 | Pride
Retina Rabbit Myopia Lc-ms/ms 
ProteomicsProteomics analysis of guinea pig retina at the early stage of myopia
This is a combined SWATH database of early myopic guinea pig retina. The retinal tissues were divided into lens induced myopia 4 days group (4-day LIM) and control group; 5 individual animals (10 retinas) were included. The potential biomarkers and underlying biochemical pathways during early myopia...
ORGANISM(S): Cavia porcellus (Guinea pig) 
2021-05-13 | PXD025003 | Pride
Proteomics guinea pig retina myopia 
ProteomicsProteomic Analysis of Retina-derived CD29 positive Müller Cells in a Myopia induced rabbit model
The prevalence of myopia is rapidly increasing, significantly impacting the quality of life for affected individuals. Prior research in our group observed reactive gliosis in Müller cells within myopia-induced retinas, prompting further investigation into their role in myopia. In this study, we anal...
ORGANISM(S): Oryctolagus cuniculus (Rabbit) 
2025-05-07 | PXD053804 | Pride
Myopia Müller cells Proteomics Oxidative stress Glycolysis 
ProteomicsLactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia
Myopia has become the major cause of visual impairment worldwide. Although the pathogenesis of myopia remains controversial, proteomics studies suggest that dysregulation of retinal metabolism is potentially involved in the pathology of myopia. Lysine lactylation of proteins plays a key role in regu...
ORGANISM(S): Cavia porcellus (Guinea pig) 
2024-10-17 | PXD046495 | Pride
Lysine lactylation Form-deprivation myopia Lactate Aerobic glycolysis Retina 
UnknownAmbient light level varies with different locations and environmental conditions: Potential to impact myopia.
Not available
S-EPMC8263252 | biostudies-literature
ProteomicsGuinea pig myopia model ocular posterior pole
Proteomic analyses of the ocular posterior pole tissues at 6 weeks after induction of form-deprived myopia and lens-induced myopia models in guinea pigs.
ORGANISM(S): Cavia Porcellus 
2022-11-01 | PXD037872 |
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