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ProteomicsMorquio A syndrome: identification of differential patterns of molecular pathway interactions in bone lesions
Mucopolysaccharidosis type IVA (MPS IVA; Morquio A syndrome) is a rare autosomal recessive lysosomal storage disease (LSD) caused by deficiency of a hydrolase enzyme, N-acetylgalactosamine-6-sulfate sulfatase, and characterized clinically by mainly musculoskeletal manifestations. The mechanisms unde...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-24 | PXD042166 | Pride
Morquio a syndrome Rare disease Swath-ms Protein biomarker 
TranscriptomicsEffect of a dual specificity PI3K/mTOR inhibitor, NVP-BEZ235, on human ovarian cancer cell lines grown in 3D culture
Analysis of the effects of a dual specificity PI3K/mTOR inhibitor on two human ovarian cell lines, OV2008 and MCAS. Results provide insight into the adaptive response to PI3K/mTOR inhibition in matrix attached ovarian cancer cells. The PI3K/mTOR-pathway is the most commonly deregulated pathway in e...
ORGANISM(S): Homo sapiens 
2012-03-13 | E-GEOD-28992 | biostudies-arrayexpress
UnknownPDGFR and IGF-1R Inhibitors Induce a G2/M Arrest and Subsequent Cell Death in Human Glioblastoma Cell Lines.
Not available
S-EPMC6162497 | biostudies-literature
UnknownFrailty transitions and associated clinical outcomes in patients with stable COPD: A longitudinal study.
Not available
S-EPMC7122798 | biostudies-literature
TranscriptomicsRole of IL-2 inducible T cell kinase (ITK) and Bruton's tyrosine kinase (BTK) in mast cell response to lipopolysaccharide (LPS)
Mast cells are indispensable for LPS-induced septic hypothermia, in which TNF-α plays an essential role to initiate sepsis. Tec family non-receptor tyrosine kinases ITK and BTK regulate mast cell-derived TNF-α in response to allergic antigen, but their role in LPS-induced TNF-α production by mast...
ORGANISM(S): Mus musculus 
2015-11-23 | E-GEOD-64287 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of Botrytis cinerea genes targeting plant cell walls of different hosts [grape]
The cell wall is among the first plant structures encountered by necrotrophic fungal pathogens, such as Botrytis cinerea. The composition of plant cell walls varies depending on the species, type of cell or tissue, and stage of development. Cell walls are important reservoirs of energy-rich sugars f...
ORGANISM(S): Vitis vinifera 
2014-09-24 | E-GEOD-57587 | biostudies-arrayexpress
UnknownA correlative biomarker study and integrative prognostic model in chemotherapy-naive metastatic castration-resistant prostate cancer treated with enzalutamide.
Not available
S-EPMC10107622 | biostudies-literature
UnknownImplementation of a Diabetes Self-Management Education and Support Intervention in Rural Guatemala: A Mixed-Methods Evaluation Using the RE-AIM Framework.
Not available
S-EPMC8673946 | biostudies-literature
UnknownDifferential Effects of IGF-1R Small Molecule Tyrosine Kinase Inhibitors BMS-754807 and OSI-906 on Human Cancer Cell Lines.
Not available
S-EPMC7763458 | biostudies-literature
UnknownEnhanced MAF Oncogene Expression and Breast Cancer Bone Metastasis.
Not available
S-EPMC4681582 | biostudies-literature
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