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ProteomicsMorc3 silences endogenous retroviruses by enabling Daxx-mediated histone H3.3 incorporation
Endogenous retroviruses (ERVs) comprise a significant portion of mammalian genomes. Although specific ERV loci feature regulatory roles for host gene expression, most ERV integrations are transcriptionally repressed by Setdb1 mediated H3K9me3 and DNA methylation. However, the protein network which r...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-03 | PXD027368 | Pride
Morc3 Endogenous retroviruses Erv Histone h3.3 Daxx Setdb1 
GenomicsMorc3 silences endogenous retroviruses in mouse embryonic stem cells [Morc3 ChIP-seq]
Morc3 silences endogenous retroviruses in mouse embryonic stem cells [Morc3 ChIP-seq]
PRJNA727553 | ENA
GenomicsMORC3 represses a tandem repeat enhancer to regulate interferon
MORC3 represses a tandem repeat enhancer to regulate interferon
PRJNA1287590 | ENA
GenomicsTranscriptional profile of MORC3 deficient BLaER1 monocytes [KO]
Transcriptional profile of MORC3 deficient BLaER1 monocytes [KO]
PRJNA757713 | ENA
GenomicsATAC-seq of MORC3 deficient BLaER1 monocytes [ATAC-seq]
ATAC-seq of MORC3 deficient BLaER1 monocytes [ATAC-seq]
PRJNA757711 | ENA
UnknownMORC3 Forms Nuclear Condensates through Phase Separation.
Not available
S-EPMC6614601 | biostudies-literature
GenomicsMorc3 silences endogenous retroviruses in mouse embryonic stem cells [Morc3_mESCs_RNAseq]
Morc3 silences endogenous retroviruses in mouse embryonic stem cells [Morc3_mESCs_RNAseq]
PRJNA727549 | ENA
GenomicsMorc3 silences endogenous retroviruses in mouse embryonic stem cells [Morc3 ChIP-seq]
Background: MORC proteins are involved in epigenetic gene silencing in a wide variety of eukaryotic organisms. Deletion of MORCs result in several developmental abnormalities and their dysregulation has been implicated in developmental disease and multiple cancers. Specifically, mutations of mammali...
ORGANISM(S): Mus musculus 
2021-10-28 | GSE173913 | GEO
GenomicsMorc3 silences endogenous retroviruses by enabling Daxx-mediated H3.3 incorporation [ATAC-seq]
Morc3 silences endogenous retroviruses by enabling Daxx-mediated H3.3 incorporation [ATAC-seq]
PRJNA670919 | ENA
GenomicsMorc3 silences endogenous retroviruses in mouse embryonic stem cells [ATAC-seq]
Morc3 silences endogenous retroviruses in mouse embryonic stem cells [ATAC-seq]
PRJNA727552 | ENA
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