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GenomicsThe DAXX co-repressor is directly recruited to active regulatory elements genome-wide to regulate autophagy programs in a model of human prostate cancer (ChIP-seq)
This study was aimed at understanding the genome-wide binding and regulatory role of the DAXX transcriptional repressor, recently implicated in PCa. ChIP-Seq analysis of genome-wide distribution of DAXX in PC3 cells revealed over 59,000 DAXX binding sites, found at regulatory enhancers and promoters...
ORGANISM(S): Homo sapiens 
2015-06-24 | E-GEOD-68647 | biostudies-arrayexpress
TranscriptomicsThe DAXX co-repressor is directly recruited to active regulatory elements genome-wide to regulate autophagy programs in a model of human prostate cancer (RNA-seq)
This study was aimed at understanding the genome-wide binding and regulatory role of the DAXX transcriptional repressor, recently implicated in PCa. ChIP-Seq analysis of genome-wide distribution of DAXX in PC3 cells revealed over 59,000 DAXX binding sites, found at regulatory enhancers and promoters...
ORGANISM(S): Homo sapiens 
2015-06-24 | E-GEOD-68645 | biostudies-arrayexpress
ProteomicsMorc3 silences endogenous retroviruses by enabling Daxx-mediated histone H3.3 incorporation
Endogenous retroviruses (ERVs) comprise a significant portion of mammalian genomes. Although specific ERV loci feature regulatory roles for host gene expression, most ERV integrations are transcriptionally repressed by Setdb1 mediated H3K9me3 and DNA methylation. However, the protein network which r...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-03 | PXD027368 | Pride
Morc3 Endogenous retroviruses Erv Histone h3.3 Daxx Setdb1 
TranscriptomicsStress-dependent CHIP/Daxx interaction suppresses the p53 apoptotic program
Our previous studies have implicated CHIP as a co-chaperone/ubiquitin ligase, whose activities yield protection against stress-induced apoptotic events. In this report, we demonstrate a stress-dependent interaction between CHIP (carboxyl terminus of Hsp70-interacting protein) and Daxx, death domain-...
ORGANISM(S): Mus musculus 
2010-04-03 | E-GEOD-14339 | biostudies-arrayexpress
GenomicsThe DAXX co-repressor is directly recruited to active regulatory elements genome-wide to regulate autophagy programs in a model of human prostate cancer
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2015-06-24 | E-GEOD-68656 | biostudies-arrayexpress
ProteomicsDAXX adds a de novo H3.3K9me3 deposition pathway to the histone chaperone network (part 2)
A multitude of histone chaperones are required to support histones from their biosynthesis until DNA deposition. They cooperate through the formation of histone co-chaperone complexes, but the crosstalk between nucleosome assembly pathways remains enigmatic. Using exploratory interactomics, we defin...
ORGANISM(S): Homo sapiens (Human) 
2023-03-02 | PXD038263 | Pride
Asf1 Nucleosome assembly Epigenetics Hjurp Nasp Histone chaperone Gene silencing Heterochromatin Daxx 
ProteomicsDAXX governs the silencing of LINE1 during spermatogenesis in mice
Total protein extraction from WT mice testes was immunoprecipitated using DAXX antibody.
ORGANISM(S): Mus Musculus 
2026-01-08 | PXD072798 |
ProteomicsDAXX adds a de novo H3.3K9me3 deposition pathway to the histone chaperone network (part 1)
A multitude of histone chaperones are required to support histones from their biosynthesis until DNA deposition. They cooperate through the formation of histone co-chaperone complexes, but the crosstalk between nucleosome assembly pathways remains enigmatic. Using exploratory interactomics, we defin...
ORGANISM(S): Homo sapiens (Human) 
2023-03-02 | PXD034888 | Pride
Asf1 Nucleosome assembly Epigenetics Hjurp Nasp Histone chaperone Gene silencing Heterochromatin Daxx 
ProteomicsHistone modifications associated with the histone chaperone DAXX
A multitude of histone chaperones is required to protect histones from their biosynthesis to DNA deposition. They cooperate through the formation of co-chaperone complexes, but the crosstalk between nucleosome assembly pathways is unclear. Using explorative interactomics approaches, we map the organ...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-06 | PXD034924 | Pride
Daxx Ptms H3.3 Histones 
GenomicsThe DAXX/ATRX Complex Protects Tandem Repetitive Elements in the Absence of DNA Methylation by Promoting H3K9 Trimethylation [ChIP-Seq]
In mammals, DNA methylation is essential for protecting repetitive sequences from aberrant transcription, translocation, and homologous recombination. However, DNA hypomethylation occurs during specific developmental stages (e.g. preimplantation embryos) and in certain cell types (e.g., primordial g...
ORGANISM(S): Mus musculus 
2015-07-15 | E-GEOD-70811 | biostudies-arrayexpress
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