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TranscriptomicsIdentification of EMT related genes in mcf10 cell line
In vitro studies on immortalized breast MCF10A cells were additionally performed to assess the phenotypic and genetic changes associated to mesenchymal transformation of breast cells and to their epithelial plasticity. To further study the molecular events associated to the cell plasticity of MCF10A...
ORGANISM(S): Homo sapiens 
2010-05-25 | E-GEOD-8430 | biostudies-arrayexpress
TranscriptomicsE-cadherin and EMT regulation by E47 transcription represor
Expression profile analysis in MDCK-E47 cells in comparisom with MDCK CMV control cells Keywords: Genetic Modification (overexpression of E-cadherin repressors) The Oncochip microarray platform v1.1 contains 9,726 clones corresponding to 6,386 different genes, and it includes 2,489 duplicate clones....
ORGANISM(S): Canis lupus familiaris 
2010-06-24 | E-GEOD-9147 | biostudies-arrayexpress
TranscriptomicsMolecular Profiling of Breast Cancer Cells after Gemcitabine exposure
Human breast cancer cell lines were exposed to IC50 gemcitabine (Gemzar) for 24 and 48 hours. RNA was extracted, amplified and hibridized onto Oncochip microarray slides. Human breast carcinoma cell lines MCF7 and MDA-MB-231 were cultured in DMEM with Glutamax-1, supplemented with 10% fetal bovine s...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-GEOD-4937 | biostudies-arrayexpress
TranscriptomicsSynergy between plasminogen activator inhibitor-1 and Snail in tumoral migration
Snail, a family of transcriptional repressors implicated in cell movement, has been correlated with tumour invasivity. The Plasminogen Activation system (PAs), including urokinase (uPA), its receptor (uPAR), and its inhibitor (PAI-1), also plays a key role in cancer invasion and metastasis, either t...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-10395 | biostudies-arrayexpress
TranscriptomicsE-cadherin and EMT regulation by bHLH factors: a new role for the class I gene E2-2 (TCF4) and its comparison with E47.
Loss of expression of the cell-cell adhesion molecule E-cadherin is an essential event for epithelial-mesenchymal transition (EMT), a process that allows cell migration in the developing embryo and during tumour invasion. Transcriptional repression has emerged as the main mechanism responsible for E...
ORGANISM(S): Canis lupus familiaris 
2010-06-24 | E-GEOD-9145 | biostudies-arrayexpress
TranscriptomicsGene expression patterns induced by 5-Fluorouracil in breast cancer cell lines
We have compared the changes in cell cycle and cell death parameters induced by 2 different concentrations of 5-FU (IC50 and IC80) in the breast adenocarcinoma cell line MCF7. G1/S cell cycle arrest was associated with both concentrations, whereas cell death was mainly induced after IC80 5-FU. These...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-GEOD-2584 | biostudies-arrayexpress
TranscriptomicsGene expression profile mediated by independent E-cadherin repressors
Gene expression profiling of MDCK epithelial cells expressing different repressors (MDCK-Snail, MDCK-Slug and MDCK-E47 cells) versus control MDCK cells. The Oncochip microarray platform v1.1 contains 9,726 clones corresponding to 6,386 different genes, and it includes 2,489 duplicate clones. Duplica...
ORGANISM(S): Canis familiaris 
2010-07-01 | E-GEOD-4151 | biostudies-arrayexpress
TranscriptomicsZeb1 and Snail1 engage miR-200f transcriptional and epigenetic regulation during EMT
Cell plasticity is emerging as a key regulator of tumor progression and metastasis. During carcinoma dissemination epithelial cells undergo epithelial to mesenchymal transition (EMT) processes characterized by the acquisition of migratory/invasive properties, while the reverse, mesenchymal to epithe...
ORGANISM(S): Canis lupus familiaris 
2014-09-09 | E-GEOD-61217 | biostudies-arrayexpress
TranscriptomicsING4 regulates a secretory phenotype in primary fibroblasts with dual effects on cell proliferation and tumor growth
ING proteins play an essential role in the control of a variety of cellular functions whose deregulation is associated with tumor formation and dissemination, such as proliferation, apoptosis, senescence or invasion. Accordingly, loss of function of ING proteins is a frequent event in many types of...
ORGANISM(S): Homo sapiens 
2013-04-22 | E-GEOD-42412 | biostudies-arrayexpress
UnknownLysyl oxidase-like 2 (LOXL2) a new regulator of cell polarity required for metastatic dissemination of basal-like breast carcinomas
Not available
ORGANISM(S): Homo sapiens 
S-ECPF-GEOD-29581 | biostudies-other
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