Sort   by:  
 Page size 
TranscriptomicsDeciphering the molecular immune response to COVID-19 using single cell multi-omics
Multi-omics single-cell profiling of surface proteins, gene expression and lymphocyte immune receptors from hospitalised COVID-19 patient peripheral blood immune cells and healthy controls donors. Identification of the coordinated immune cell compositional and state changes in response to SARS-CoV-2...
ORGANISM(S): Homo sapiens 
2021-03-17 | E-MTAB-10026 | biostudies-arrayexpress
ProteomicsMudPIT analyses of the human proteins biotinylated by proximity to biotin ligase (BioID) fused to the C-terminus of activators of the dynein/dynactin motor
To understand how a single motor achieves cargo specificity, we attached a promiscuous biotin ligase (BioID) to 6 distinct activators of the dynein machinery motile activity, including two new activators, ninein and ninein-like. BioID experiments were performed with stable HEK293 cell lines expressi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-30 | MSV000080808 | MassIVE
TranscriptomicsCharting the age-altered thymic epithelial cell differentiation by lineage tracing from a beta 5-t expressing TEC progenitor
TEC progenitors that express beta 5-t contribute to both the cortical and medullary TEC compartments. Our initial experiments across ageing thymi identified a population of potential progenitor TECs which expanded with age, and appears to be a progenitor population for mTEC. These lineage tracing ex...
ORGANISM(S): Mus musculus 
2020-09-14 | E-MTAB-8737 | biostudies-arrayexpress
ProteomicsMudPIT analyses of the human proteins biotinylated by proximity to exogenously expressed biotin ligase (BioID)
To identify non-specific biotinylation events, HEK293 cells transfected with a plasmid carrying only the biotin ligase moiety were used as negative controls to BioID experiments. Cells were lysed in the presence of detergents. After purification of biotinylated proteins on streptavidin-conjugated be...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-30 | MSV000080809 | MassIVE
TranscriptomicsSarcoptes scabiei Mites Modulate Gene Expression In Human Skin Equivalents
The purpose of this study was to identify genes in keratinocytes and fibroblasts in human skin equivalents that changed expression in response to the burrowing of live scabies mites. Four biological replicates for the uninfested control condition and five biological replicates for the treatment cond...
ORGANISM(S): Homo sapiens 
2013-07-03 | E-GEOD-48459 | biostudies-arrayexpress
UnknownIntrinsic PARG inhibitor sensitivity is mimicked by TIMELESS haploinsufficiency and rescued by nucleoside supplementation.
Not available
S-EPMC11249981 | biostudies-literature
ProteomicsImpaired presynaptic proteostasis in the initial stages of amyloid beta proteotoxicity
Compromised protein homeostasis underlies accumulation of plaques and tangles in Alzheimers disease (AD); however, little is known about the early mechanisms that contribute to this accumulation. To objectively assess the impaired protein turnover at early stages of amyloid beta (Abeta) proteotoxic...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-02-24 | MSV000085004 | MassIVE
TranscriptomicsTissue inflammation reprograms lymphatic collectors to support entry and rapid migration of dendritic cells to draining lymph nodes
Afferent lymphatic vessels (LVs) connect peripheral tissues with draining lymph nodes (dLNs) and are important for immune-surveillance and tissue drainage. They begin in the tissue as initial lymphatic capillaries, which are highly permeable and branched vessels specialized in the uptake of macromol...
ORGANISM(S): Mus musculus 
2021-05-07 | E-MTAB-9175 | biostudies-arrayexpress
UnknownHeptavalent pneumococcal conjugate vaccine immunogenicity in very-low-birth-weight, premature infants.
Not available
S-EPMC2949965 | biostudies-literature
UnknownComparative Molecular Analysis of Gastrointestinal Adenocarcinomas.
Not available
S-EPMC5966039 | biostudies-literature
Sort   by:  
 Page size