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Elongator is a tRNA-modifying complex regulating protein translation. Recently, a moonlighting function of Elongator has been identified in regulating the polarization of the microtubule cytoskeleton during asymmetric cell division. Elongator induces symmetry breaking of the anaphase midzone by sele...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2025-05-07 | PXD058480 | Pride
we describe a general approach for de novo design of proteins made out of repeating units that bind peptides with repeating sequences such that there is a one to one correspondence between repeat units on the protein and peptide. We develop a rapid docking plus geometric hashing method to identify p...
ORGANISM(S): Homo sapiens (Human) 
2023-03-17 | PXD038492 | Pride
Myosin VI (Myo6) is the only minus-end directed nanomotor on actin, allowing it to uniquely contribute to numerous cellular functions. As for other nanomotors, proper functioning of Myo6 relies on precise spatio-temporal control of motor activity via a poorly defined off-state and interactions with ...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD044767 | Pride
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