Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Hela Cell
SUBMITTER: Tomos Morgan
LAB HEAD: Emmanuel Derivery
PROVIDER: PXD038492 | Pride | 2023-03-17
REPOSITORIES: Pride
Wu Kejia K Bai Hua H Chang Ya-Ting YT Redler Rachel R McNally Kerrie E KE Sheffler William W Brunette T J TJ Hicks Derrick R DR Morgan Tomos E TE Stevens Tim J TJ Broerman Adam A Goreshnik Inna I DeWitt Michelle M Chow Cameron M CM Shen Yihang Y Stewart Lance L Derivery Emmanuel E Silva Daniel Adriano DA Bhabha Gira G Ekiert Damian C DC Baker David D
Nature 20230405 7957
General approaches for designing sequence-specific peptide-binding proteins would have wide utility in proteomics and synthetic biology. However, designing peptide-binding proteins is challenging, as most peptides do not have defined structures in isolation, and hydrogen bonds must be made to the buried polar groups in the peptide backbone<sup>1-3</sup>. Here, inspired by natural and re-engineered protein-peptide systems<sup>4-11</sup>, we set out to design proteins made out of repeating units t ...[more]