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ProteomicsItch Ubiquitin Ligase Deficiency and B cell LC-MSMS
The E3 ubiquitin ligase Itch regulates antibody levels and prevents autoimmune disease in humans and mice, yet how Itch regulates B cell fate or function is unknown. We now show that Itch directly limits B cell activity. Using LC-MSMS, we profiled and compared the whole cell proteomes of Itch defici...
ORGANISM(S): Mus musculus (Mouse) 
2019-07-12 | PXD014243 | Pride
Itch ubiquitin ligase Lc-msms Tlr9 B cell 
ProteomicsThe Ubiquitin Ligase Itch Skews Light Zone Selection in Germinal Centers
Ig diversification occurs in peripheral lymphoid organs after establishment of central tolerance during B cell development. In germinal centers (GCs), somatic hypermutation of Ig genes occurs in dark zones, followed by selection of mutated clones in light zones (LZs). This generates high-affinity Ig...
ORGANISM(S): Mus musculus (Mouse) 
2024-11-12 | PXD040978 | Pride
B-cell Germinal center Autoimmunity Ubiquitin ligase 
UnknownComplete mitochondrial genome of the Satanas beetle, Dynastes satanas Moser, 1909 (Coleoptera: Scarabaeidae).
Not available
S-EPMC11613335 | biostudies-literature
UnknownB cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5.
Not available
S-EPMC2212150 | biostudies-literature
UnknownThe E3 ubiquitin ligase Itch restricts antigen-driven B cell responses.
Not available
S-EPMC6719427 | biostudies-literature
UnknownB-Cell Homeostasis Is Maintained During Two Months of Head-Down Tilt Bed Rest With or Without Antioxidant Supplementation.
Not available
S-EPMC8892569 | biostudies-literature
UnknownInhibition of hepatic scavenger receptor-class B type I by RNA interference decreases atherosclerosis in rabbits.
Not available
S-EPMC3405511 | biostudies-literature
UnknownB cell expression of E3 ubiquitin ligase Cul4b promotes chronic gammaherpesvirus infection in vivo.
Not available
S-EPMC10734415 | biostudies-literature
UnknownPseudomonas aeruginosa infection liberates transmissible, cytotoxic prion amyloids.
Not available
S-EPMC5471513 | biostudies-literature
TranscriptomicsGenome-wide analysis of gene expression in Eµ-Myc and Eµ-Myc Wrn Δhel/Δhel murine lymphomas
Transcriptional profiling Myc-driven lymphomas to determine pathways by which Wrn deficiency impairs tumor development Total RNA isolated from Eµ-Myc and Eµ-Myc Wrn Δhel/Δhel murine B-cell lymphomas (n=4)
ORGANISM(S): Mus musculus 
2012-02-25 | E-GEOD-25671 | biostudies-arrayexpress
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