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TranscriptomicsSmoking is Associated with Shortened Airway Cilia
Background: Whereas cilia damage and reduced cilia beat frequency have been implicated as causative of reduced mucociliary clearance in smokers, theoretically mucociliary clearance could also be affected by cilia length. Based on models of mucociliary clearance predicting cilia length must exceed th...
ORGANISM(S): Homo sapiens 
2012-12-13 | E-GEOD-16696 | biostudies-arrayexpress
TranscriptomicsAltered Expression of Intraflagellar Transport Genes is Associated with Short Cilia in Smoking and COPD
Study Smoking and COPD are associated with decreased mucociliary clearance and healthy smokers have shorter cilia in the large airway than nonsmokers. Intraflagellar transport (IFT) is the process by which cilia are produced and maintained. We assessed expression of IFT-related genes in smokers and ...
ORGANISM(S): Homo sapiens 
2014-02-03 | E-GEOD-43939 | biostudies-arrayexpress
TranscriptomicsGene expression in control and cilia deleted growth plate chondrocytes
Proliferative zone chondrocytes were microdissected from control and Ift88-deleted growth plates to determine gene expression profiles regulated by primary cilia. Four total samples were analyzed. Two biological replicates of proliferative zone chondrocytes microdissected from control mice and two b...
ORGANISM(S): Mus musculus 
2013-01-02 | E-GEOD-35003 | biostudies-arrayexpress
ProteomicsDSSO Crosslinking of Intact Tetrahymena Thermophila Cilia
The MS-cleavable crosslinker, DSSO, was added to cilia isolated from Tetrahymena thermophila. After digestion crosslinked peptides were enriched by size exclusion chromatography. Data were collected using an MS2/MS3 method. Analysis was done using the XlinkX node of PD2.3 and a fasta file generat...
ORGANISM(S): Tetrahymena Thermophila (ncbitaxon:5911) 
2022-07-19 | MSV000089917 | MassIVE
TranscriptomicsGenome-wide gene expression analysis in primary ciliary dyskinesia patients
We performed whole genome gene expression profiling in bronchial biopsies from PCD patients. We used the Quality Threshold clustering algorithm to identify groups of genes that revealed highly correlated RNA expression patterns in the biopsies. The largest cluster contained 372 genes and was signifi...
ORGANISM(S): Homo sapiens 
2015-02-24 | E-GEOD-25186 | biostudies-arrayexpress
UnknownCilia density and flow velocity affect alignment of motile cilia from brain cells.
Not available
S-EPMC7790191 | biostudies-literature
GenomicsMotile cilia modulate neuronal and astroglial activity in the zebrafish larval brain
Motile cilia modulate neuronal and astroglial activity in the zebrafish larval brain
PRJNA1068100 | ENA
GenomicsCerebrospinal fluid-driven ependymal motile cilia defects are implicated in multiple sclerosis
Cerebrospinal fluid-driven ependymal motile cilia defects are implicated in multiple sclerosis
PRJNA1285692 | ENA
GenomicsThe Ciliary GTPase ARL13B maintains Ductule Physiology through the Primary and Motile Cilia in Male Reproduction
The Ciliary GTPase ARL13B maintains Ductule Physiology through the Primary and Motile Cilia in Male Reproduction
PRJNA1079343 | ENA
UnknownEntrainment of mammalian motile cilia in the brain with hydrodynamic forces.
Not available
S-EPMC7165462 | biostudies-literature
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