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ProteomicsNicheProt: Cell-type-resolved proteomics of mouse spleen tissue compartments
This dataset contains proteomic analyses that validate the spatial proteomic technology, NicheProt, and its application to investigate dendritic cell phenotypes in inflammed mouse spleens. NicheProt is a 3D optical microscopy-guided, photobleaching-mediated cell barcoding approach to isolate intact ...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-19 | PXD075718 | Pride
Microscopy Dendritic cells Inflammation Cell barcoding Spatial proteomics 
TranscriptomicsClassical dendritic cells are required for dietary antigen-mediated peripheral regulatory T cell and tolerance induction II
Oral tolerance prevents pathological inflammatory responses towards innocuous foreign antigens via peripheral regulatory T cells (pTreg cells). However, whether a particular subset of antigen-presenting cells (APCs) is required during dietary antigen exposure to instruct naïve CD4+ T cells to diffe...
ORGANISM(S): Mus musculus 
2016-03-28 | E-GEOD-77304 | biostudies-arrayexpress
ProteomicsIron flux in plasmacytoid dendritic cells; potential role for transferrin receptor beyond iron metabolism
Plasmacytoid dendritic cells (pDCs) are critical antiviral sentinels known for rapid type I interferon (IFN-I) production. However, their proteomic profile and nutrient dependencies are not well understood. Here, we used absolute quantitative proteomics of ex vivo murine splenic pDCs to characterize...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-29 | PXD079623 | Pride
Transferrin receptor  dendritic cell  iron 
ProteomicsLabel free quantitative (LFQ) proteomic analysis of mouse lymphatic endothelial cells and primary mouse dendritic cells in response to IFNgamma treatment in presence or absence of 3-HKA
To explore the cellular pathways and the molecular functions affected by a novel biogenic amine, (3-HKA), we performed a label free quantitative (LFQ) proteomic analysis of mouse lymphatic endothelial cells (LEC), and primary dendritic cells, treated with IFNgammaplus or minus 3-HKA. Biological tri...
ORGANISM(S): Mus musculus (Mouse) 
2021-07-28 | PXD015865 | Pride
Mouse lymphatic endotehlial cells (lec)  mouse primary dendritic cells (pdc)  nanolc-ms/ms 
ProteomicsLabel-free comparative data independent (DIA) nanoLC-MS/MS analysis of protein expression profiles of mouse primary dendritic cells (DC) from B6 mice on normal and high fructose/high fat (HFHF) diet
A diet rich in saturated fat and carbohydrates causes a low-grade chronic inflammation in several organs including nonalcoholic steatohepatitis. The environment-driven lipotocicity and glucotoxicity induce tissue damage, which promotes dendritic cell adjuvanticity, and supports an MHC-class-II immun...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-22 | PXD026190 | Pride
Mouse dendritic cells (cd11c+) proteomics  dia/dda nano lc-ms/ms orbitrap fusion tribrid mass spectrometer 
ProteomicsLabel-free comparative data dependent (DDA) nanoLC-MS/MS analysis of redox mediated posttranslational modifications (PTMs) in the proteomes from mouse primary dendritic cells (DC) isolated from control B6 and obese (Ob/Ob) mice
Proteomic modifications linked to non-enzymatic glycation and glycoxidation are common in all tissues under hyperglycemic conditions, as present in metabolic syndrome, type 2 diabetes (T2D), mice bearing a homozygous mutation in leptin (so-called Ob/Ob mice, a common model of obesity and T2D) and mi...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-21 | PXD024239 | Pride
Control b6 and ob/ob mice dendritic cells Bottom-up proteomics on qehf and velos orbitrap 
TranscriptomicsClassical dendritic cells are required for dietary antigen-mediated peripheral regulatory T cell and tolerance induction
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2016-03-28 | E-GEOD-77305 | biostudies-arrayexpress
ProteomicsCharacterization of I-Ab MHCII immunopeptidome eluted from control and obese (Ob/Ob) mice (2)
In Dendritic cells (DC), the MHC II eluted immunopeptidome reflects the antigenic composition of the microenvironment. Proteins are transported and processed into peptides in endosomal MHC II compartments through autophagy or phagocytosis; extracellular peptides can also directly bind MHC II protein...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-21 | PXD018783 | Pride
Mouse i-ab mhcii peptidome  lc/ms/ms dda on qe mass spectrometer 
ProteomicsCharacterization of I-Ab MHCII immunopeptidome eluted from control and obese (Ob/Ob) mice using a combination of data-dependent (DDA) and data-independent acquisition (DIA) nanoLC mass spectrometry
In Dendritic cells (DC), the MHC II eluted immunopeptidome reflects the antigenic composition of the microenvironment. Proteins are transported and processed into peptides in endosomal MHC II compartments through autophagy or phagocytosis; extracellular peptides can also directly bind MHC II protein...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-21 | PXD023581 | Pride
Mouse dendritic cells  i-ab mhc-ii immunopeptidome  dda and dia nanolcms 
ProteomicsNano LC-MS/MS DDA mass spectrometry profiling of I-Ab MHCII immunopeptidome eluted from B6 mice on normal and high fructose/high fat (HFHF) diet
In Dendritic cells (DC), the MHC II eluted immunopeptidome reflects the antigenic composition of the microenvironment. Proteins are transported and processed into peptides in endosomal MHC II compartments through autophagy or phagocytosis; extracellular peptides can also directly bind MHC II protein...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-22 | PXD026068 | Pride
Mouse i-ab immunopeptidome  dda nanolc-ms/ms  orbitrap fusion tribrid mass spectrometer 
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