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MetabolomicsMacrophage-mediated antibiotic evasion and competitive dominance of mcr-3-carrying Escherichia coli

Mobile colistin resistance (mcr) genes undermine the efficacy of last-line polymyxin antibiotics, and the global prevalence of mcr-3 continues to rise despite reduced colistin use. Here, we show that mcr-3-positive Escherichia coli (E. coli) confers a survival advantage by reprogramming macrophag...

2026-05-30 | MTBLS13550 | MetaboLights
MetabolomicsAggressive breast cancers secrete heme metabolites to alter macrophage immune suppression and function
The heme catabolism pathway is often elevated in aggressive cancers; however, the impact of this pathway and some of its byproducts on the tumor microenvironment remain largely unknown. In human breast cancers, tumor expression of the heme catabolizing enzyme heme oxygenase-1 (HO-1/HMOX1) is positiv...
2026-04-24 | MTBLS14278 | MetaboLights
ProteomicsDataset of proteins of mouse macrophage cell line PMJ2R samples infected with Tick-borne encephalitis virus, strain Hypr original isolate (part 2)
Dataset for a comparative analysis of protein profiles of three series of mouse macrophage cell line PMJ2R samples including infected with Tick-borne encephalitis virus, strain Hypr original isolate on the second (H2) and sixth day (H6) after infection was carried out using shotgun ultra-high resolu...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-11 | PXD016227 | Pride
Shotgun mass spectrometry Tbev Mouse macrophage cell line Protein 
TranscriptomicsTranscription profiling of bone marrow macrophages (BMM), BMM co-cultured with breast cancer cell line 4T1.2, and RAW macrophage cell line
Exon ST arrays were used to compare gene expression in bone marrow macrophages (BMM), BMM co-cultured with breast cancer cell line 4T1.2, RAW macrophage cell lines, and tumour supernatant.
ORGANISM(S): Mus musculus 
2019-11-16 | E-MTAB-4064 | biostudies-arrayexpress
MetabolomicsCell of origin epigenetic priming determines susceptibility to Tet2 mutation

Hematopoietic stem cell (HSC) mutations can result in clonal hematopoiesis (CH) with heterogeneous clinical outcomes. Here, we investigated how the cell state preceding Tet2 mutation impacts the pre-malignant phenotype. Using an inducible system for clonal analysis of myeloid progenitors...

2024-04-30 | MTBLS9914 | MetaboLights
ProteomicsDataset of proteins of mouse macrophage cell line PMJ2R samples infected with Tick-borne encephalitis virus, strain Hypr original isolate
Dataset for a comparative analysis of protein profiles of three series of mouse macrophage cell line PMJ2R samples including the control uninfected series (sample M) and infected with Tick-borne encephalitis virus, strain Hypr original isolate on the second (H2) and sixth day (H6) after infection wa...
ORGANISM(S): Mus musculus (Mouse) Tick-borne encephalitis virus 
2019-10-23 | PXD015164 | Pride
Tbev hypr Mouse macrophage Protein Label-free quantification Panoramic mass spectrometry 
TranscriptomicsTranscription profiling of mouse macrophages infected with B. melitensis
Facultative intracellular Brucella infect and survive inside macrophages, and the outcome of macrophage-Brucella interaction is a basis for establishment of a chronic Brucella infection. The majority of Brucella are killed at the early infection stage. A subpopulation of virulent Brucella strains is...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5202 | biostudies-arrayexpress
MetabolomicsMetabolic profiling of ob/ob mouse fatty liver using HR-MAS 1H-NMR combined with gene expression analysis reveals alterations in betaine metabolism and the transsulfuration pathway
Metabolic perturbations resulting from excessive hepatic fat accumulation are poorly understood. Thus, in this study, leptin-deficient ob/ob mice, a mouse model of fatty liver disease, were used to investigate metabolic alterations in more detail. Metabolites were quantified in intact liver tissues ...
2018-01-31 | MTBLS400 | MetaboLights
TranscriptomicsSimple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities
Genome-scale studies have revealed extensive co-localization of transcription factors in a given cell type as well as substantial differences in the binding patterns of specific transcription factors between cell types. Several mechanisms have been proposed to explain these observations, including t...
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-21512 | biostudies-arrayexpress
TranscriptomicsRev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription
Rev-Erba and Rev-Erbb are nuclear receptors that regulate the expression of genes involved in the control of circadian rhythm, metabolism, and inflammatory responses. Rev-Erbs function as transcriptional repressors by recruiting NCoR/HDAC3 co-repressor complexes to Rev-Erb response elements in enha...
ORGANISM(S): Mus musculus 
2013-06-05 | E-GEOD-45914 | biostudies-arrayexpress
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