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MetabolomicsOligofructose alleviates hyperandrogenism in polycystic ovary syndrome through gut microbiota-derived bile acids

Bile acid profiles from fecal and serum samples of letrozole-induced PCOS mouse model treated with oligofructose. Results provide insight into the bile acid changes caused by letrzole and oligofructose.

2026-02-27 | MTBLS8525 | MetaboLights
MetabolomicsEffects of Yulin Tong Bu formula on modulating gut microbiota and fecal metabolite interactions in mice with polycystic ovary syndrome

BACKGROUND: Polycystic ovarian syndrome (PCOS) is a common endocrine disorder characterized by hyperandrogenism, ovarian dysfunction and polycystic ovarian morphology. Gut microbiota dysbiosis and metabolite are associated with PCOS clinical parameters. Yulin Tong Bu formula (YLT...

2023-02-02 | MTBLS6736 | MetaboLights
MetabolomicsAndrogens drive SLC1A5-dependent metabolic reprogramming in polycystic ovary syndrome-GC-MS analysis of follicular fluid
Polycystic ovary syndrome (PCOS) is the primary cause of female infertility. Growing evidence suggests that dysregulation of amino acid metabolism plays a significant role in the onset and progression of PCOS. However, the underlying mechanism remains unclear. In this study, we conducted targeted me...
2025-04-14 | MTBLS12371 | MetaboLights
MetabolomicsAndrogens drive SLC1A5-dependent metabolic reprogramming in polycystic ovary syndrome-GC-MS analysis of KGN cells

Polycystic ovary syndrome (PCOS) is the primary cause of female infertility. Growing evidence suggests that dysregulation of amino acid metabolism plays a significant role in the onset and progression of PCOS. However, the underlying mechanism remains unclear. In this study, we conducted targeted...

2025-04-14 | MTBLS12370 | MetaboLights
MetabolomicsAndrogens drive SLC1A5-dependent metabolic reprogramming in polycystic ovary syndrome-LC-MS analysis of granulosa cells

Polycystic ovary syndrome (PCOS) is the primary cause of female infertility. Growing evidence suggests that dysregulation of amino acid metabolism plays a significant role in the onset and progression of PCOS. However, the underlying mechanism remains unclear. In this study, we conducted targeted...

2025-04-14 | MTBLS12367 | MetaboLights
TranscriptomicsFoxl2 functions throughout mouse ovary development
This SuperSeries is composed of the following subset Series: GSE12905: Foxl2 functions in sex determination and histogenesis throughout mouse ovary development, analyzed by Affymetrix arrays GSE12942: Foxl2 functions in sex determination and histogenesis throughout mouse ovary development, analyzed ...
ORGANISM(S): Mus musculus 
2010-05-17 | E-GEOD-12989 | biostudies-arrayexpress
ProteomicsIdentification of co-factors of eIF4E1b protein in mouse ovary.
We have identified eukaryotic translation initiation factor 4E family member 1B (Eif4e1b) as a regulator of maternal RNA translation, whose maternal deletion leads to 2-cell arrest phenotype in mouse embryos. eIF4E1b protein binds mRNA selectively in oocytes and controls their translation in early e...
ORGANISM(S): Mus musculus (Mouse) 
2023-06-12 | PXD041622 | Pride
Mouse Initiation facto Eif-4e1b Affinity Ovary 
ProteomicsI.e. mouse ovary palmitoylation protein LC-MSMS
To identify a role for protein palmitoylation in ovarian of DHEA-induced PCOS mice model. First, we used DHEA to induce a PCOS mice model，hematoxylin-eosin (H&E) staining sections form the ovaries of the Control and DHEA groups.The mice oral gavage with DHEA disrupted ovarian morphology,the estrous ...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD028835 | Pride
I.e. mouse ovary， palmitoylation protein， lc-msms 
TranscriptomicsEffects of Aging and Calorie Restriction on the Global Gene Expression Profiles of Mouse Testis and Ovary
AGEMAP is an initiative of the National Institute on Aging (NIA) designed to study the aging process on mice with Caloric Restriction (CR) versus Ad Libitum (AL) diet. The aim of the AGEMAP project is to provide a valuable source of information about genetic influences involved in aging of the major...
ORGANISM(S): Mus musculus 
2010-05-26 | E-GEOD-7502 | biostudies-arrayexpress
TranscriptomicsFoxl2 functions in sex determination and histogenesis throughout mouse ovary development, analyzed by Agilent arrays
Partial loss of function of the transcription factor FOXL2 leads to premature ovarian failure in women. In animal models, Foxl2 is required for maintenance, and possibly induction, of female sex determination independently of other critical genes, i.e., Rspo1 and Wnt4. Here we report expression prof...
ORGANISM(S): Mus musculus 
2010-05-17 | E-GEOD-12942 | biostudies-arrayexpress
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