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ProteomicsmPFC Synaptosome Proteomics Reveals Novel Pathways and Muscarinic Receptor Changes in a Learned Helplessness Mouse Model
Stressful events are a leading factor in development of depression. The medial prefrontal cortex (mPFC) is strongly associated with depression etiology and exposure to uncontrollable stressors results in synaptic dysfunction and loss. Learned helplessness is a behavioral paradigm that measures effec...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-20 | PXD073765 | Pride
Mpfc Acetylcholine Major depressive disorder Stress models Learned helplessness Muscarinic receptors Proteomics 
ProteomicsProteomic profiling of astrocytic O-GlcNAc transferase related proteins in the mPFC
Our research showed that astrocytic OGT could influence the expression of proteins in the mPFC. Most of these altered proteins participate in metabolic process, transferase activity, and biosynthetic process. GFAP, an astrocyte maker, was increased after OGT deletion. These results provide a framewo...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-02 | PXD026887 | Pride
O-glcnac transferase Mpfc Proteomic Astrocyte 
GenomicsExpression data from Drd2+ cells of mouse mPFC
Expression data from Drd2+ cells of mouse mPFC
PRJNA476361 | ENA
GenomicsA genetically defined mPFC-thalamic circuit underlies pain chronicity
A genetically defined mPFC-thalamic circuit underlies pain chronicity
PRJNA1016417 | ENA
GenomicsmicroRNA expression data from medial prefrontal cortex (mPFC) of Rat
microRNA expression data from medial prefrontal cortex (mPFC) of Rat
PRJNA416278 | ENA
GenomicsRNAseq of P8 mPFC after BDNF forms expression induction
Transriptional profile of various BDNF forms increased expression in rat neonatal mPFC.
PRJEB47241 | ENA
GenomicsTotal RNA-seq from mice of NAc and mPFC
Total RNA-seq from mice of NAc and mPFC
PRJNA1088184 | ENA
GenomicsImpact of NPAS2 on mPFC dopamine synthesis and nap behavior
Impact of NPAS2 on mPFC dopamine synthesis and nap behavior
PRJNA1415761 | ENA
ProteomicsEffect of TSP1 on peotein expression of mice mPFC
To investigate the role of TSP1 in the brain, we established the mPFC in mice after treatment with recombinant human thrombospondin-1 protein i.p.
ORGANISM(S): Mus <genus> 
2023-03-07 | PXD040646 |
GenomicsEffect of TSP1 on gene expression of mice mPFC
Effect of TSP1 on gene expression of mice mPFC
PRJNA942936 | ENA
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