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ProteomicsTranslatome analyses by bio-orthogonal non-canonical amino acid labeling reveal that MR1-activated MAIT cells induce an M1 phenotype and antiviral programming in antigen-presenting monocytes_monocellular
MAIT cells are multifunctional innate-like effector cells recognizing bacterial-derived vitamin B metabolites presented by the non-polymorphic MHC class I related-1 molecule (MR1). Activated MAIT cells can exert regulatory, pro-inflammatory, or cytotoxic responses that enable the direct killing of i...
ORGANISM(S): Homo sapiens (Human) 
2023-02-08 | PXD039820 | Pride
Boncat Mait cell Antiviral Translatome Mr1-mediated mait cell activation M1 macrophage polarization Proteomics 
ProteomicsTranslatome analyses by bio-orthogonal non-canonical amino acid labeling reveal that MR1-activated MAIT cells induce an M1 phenotype and antiviral programming in antigen-presenting monocytes_bicellular2
MAIT cells are multifunctional innate-like effector cells recognizing bacterial-derived vitamin B metabolites presented by the non-polymorphic MHC class I related-1 molecule (MR1). Activated MAIT cells can exert regulatory, pro-inflammatory, or cytotoxic responses that enable the direct killing of i...
ORGANISM(S): Homo sapiens (Human) 
2023-02-08 | PXD039804 | Pride
Boncat Mait cell Antiviral Translatome Mr1-mediated mait cell activation M1 macrophage polarization Proteomics 
ProteomicsTranslatome analyses by bio-orthogonal non-canonical amino acid labeling reveal that MR1-activated MAIT cells induce an M1 phenotype and antiviral programming in antigen-presenting monocytes_bicellular1
MAIT cells are multifunctional innate-like effector cells recognizing bacterial-derived vitamin B metabolites presented by the non-polymorphic MHC class I related-1 molecule (MR1). Activated MAIT cells can exert regulatory, pro-inflammatory, or cytotoxic responses that enable the direct killing of i...
ORGANISM(S): Homo sapiens (Human) 
2023-02-08 | PXD039785 | Pride
Boncat Mait cell Antiviral Translatome Mr1-mediated mait cell activation M1 macrophage polarization Proteomics 
ProteomicsTranslatome analyses by bio-orthogonal non-canonical amino acid labeling reveal that MR1-activated MAIT cells induce an M1 phenotype and antiviral programming in antigen-presenting monocytes_bicellular 3
MAIT cells are multifunctional innate-like effector cells recognizing bacterial-derived vitamin B metabolites presented by the non-polymorphic MHC class I related-1 molecule (MR1). Activated MAIT cells can exert regulatory, pro-inflammatory, or cytotoxic responses that enable the direct killing of i...
ORGANISM(S): Homo sapiens (Human) 
2023-02-08 | PXD039810 | Pride
Boncat Mait cell Antiviral Translatome Mr1-mediated mait cell activation M1 macrophage polarization Proteomics 
UnknownVirus-Mediated Suppression of the Antigen Presentation Molecule MR1.
Not available
S-EPMC7798347 | biostudies-literature
UnknownSuppression of MR1 by human cytomegalovirus inhibits MAIT cell activation.
Not available
S-EPMC9950634 | biostudies-literature
UnknownProtective effect of TCR-mediated MAIT cell activation during experimental autoimmune encephalomyelitis.
Not available
S-EPMC11519641 | biostudies-literature
UnknownType I interferons drive MAIT cell functions against bacterial pneumonia.
Not available
S-EPMC10373297 | biostudies-literature
UnknownTuning of human MAIT cell activation by commensal bacteria species and MR1-dependent T-cell presentation.
Not available
S-EPMC6279574 | biostudies-literature
TranscriptomicsSynergistic role of riboflavin-auxotrophic Enterococcus for MR1 expression and in-tra-tumoral mucosal associated invariant T (MAIT) cell activation
The role of mucosal invariant T (MAIT) cells in the lung tumor microenvironment re-mains poorly understood, especially in the setting of immune checkpoint inhibitors. We identified intratumoral MAIT cells from paired single cell RNA and TCR sequencing datasets of tumor infil-trating CD3 T cells isol...
ORGANISM(S): Homo sapiens 
2026-02-23 | GSE320009 | GEO
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