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MetabolomicsGPR109a-AMPK Axis Mediates the Attenuation of Uric Acid-Induced M1 Macrophage Polarization by β-hydroxybutyrate from Lacticaseibacillus rhamnosus M2b

Hyperuricemia (HUA) is a metabolic disorder marked by increased blood uric acid (UA) levels, closely linked to conditions such as gout. UA-induced macrophage M1 polarization fundamentally exacerbates inflammatory pathophysiology, but current HUA-specific immunoregulatory treatments are inadequat...

2026-01-26 | MTBLS13224 | MetaboLights
TranscriptomicsHost responses contributing to the attenuation of severe acute respiratory syndrome coronaviruses missing E protein domains
Severe acute respiratory syndrome coronavirus (SARS-CoV) causes a respiratory disease leading to death in 10% of the infected people. A mouse adapted SARS-CoV lacking the envelope (E) protein (rSARS-CoV-MA15-?E) is attenuated in vivo. To identify E protein domains and host responses that contribute ...
ORGANISM(S): Mus musculus 
2015-05-19 | E-GEOD-59185 | biostudies-arrayexpress
ProteomicsMusashi interaction with poly(A) binding protein is required for activation of target mRNA translation
The Musashi family of mRNA translational regulators control both physiological and pathological stem cell self-renewal primarily by repressing targets that promote differentiation. In response to differentiation cues, Musashi can switch from a repressor to an activator of target mRNA translation. ...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2019-05-31 | PXD013585 | Pride
Musashi Stem cell Mrna translation Pabp Oocyte 
GenomicsMechanism of virus attenuation by codon pair deoptimization
Mechanism of virus attenuation by codon pair deoptimization
PRJNA556267 | ENA
ProteomicsGRK4 causes renal mitochondrial dysfunction and hypertension by accelerating COX6B1 mRNA attenuation via Lamin A/C phosphorylation and METTL14 upregulation
Background: G-protein-coupled receptor kinase 4 (GRK4) and mitochondria are involved in the pathogenesis of hypertension. However, whether renal GRK4 regulates mitochondrial function in hypertension is unknown. Methods: Blood pressure and renal tubular mitochondrial ultrastructure and function were ...
ORGANISM(S): Rattus Norvegicus 
2026-09-13 | PXD084134 |
TranscriptomicsSequence selectivity of macrolide-induced translational regulation
We sequenced a total of 12 cDNA libararies derived from fragmented total mRNA and ribosome protected mRNAs from azithromycin-treated and -untreated S. aureus samples. The data represented 2 independent biological replicates. Examination of the impact of azithromycin on global translatome, mRNA abund...
ORGANISM(S): Staphylococcus aureus subsp. aureus NCTC 8325 
2014-11-03 | E-GEOD-57175 | biostudies-arrayexpress
UnknownMarkers of angiogenesis associated with surgical attenuation of congenital portosystemic shunts in dogs.
Not available
S-EPMC4895587 | biostudies-literature
TranscriptomicsHost responses contributing to the attenuation of severe acute respiratory syndrome coronaviruses missing E protein domains
Severe acute respiratory syndrome coronavirus (SARS-CoV) causes a respiratory disease leading to death in 10% of the infected people. A mouse adapted SARS-CoV lacking the envelope (E) protein (rSARS-CoV-MA15-ΔE) is attenuated in vivo. To identify E protein domains and host responses that contribute ...
ORGANISM(S): Mus musculus 
2015-05-19 | GSE59185 | GEO
UnknownCCI-779 inhibits cell-cycle G2-M progression and invasion of castration-resistant prostate cancer via attenuation of UBE2C transcription and mRNA stability.
Not available
S-EPMC3138908 | biostudies-literature
UnknownAttenuation of nonsense-mediated mRNA decay facilitates the response to chemotherapeutics.
Not available
S-EPMC4375787 | biostudies-literature
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