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TranscriptomicsGenome-wide analysis of Musashi-2 targets reveals novel functions in governing epithelial cell migration
The Musashi-2 (Msi2) RNA-binding protein maintains stem cell self-renewal and promotes oncogenesis by enhancing cell proliferation in hematopoietic and gastrointestinal tissues. However, it is unclear how Msi2 recognizes and regulates mRNA targets in vivo and whether Msi2 primarily controls cell gro...
ORGANISM(S): Mus musculus 
2016-04-01 | E-GEOD-71333 | biostudies-arrayexpress
TranscriptomicsMusashi 2 regulates normal hematopoiesis and accelerates leukemogenesis
This SuperSeries is composed of the following subset Series: GSE16432: MSI2 regulates hematopoiesis and accelerates leukemogenesis GSE22773: Musashi 2 regulates normal hematopoiesis and accelerates leukemogenesis (LK and MS12-inducible) GSE22774: Musashi 2 regulates normal hematopoiesis and accelera...
ORGANISM(S): Homo sapiens 
2010-07-21 | E-GEOD-22778 | biostudies-arrayexpress
ProteomicsMusashi interaction with poly(A) binding protein is required for activation of target mRNA translation
The Musashi family of mRNA translational regulators control both physiological and pathological stem cell self-renewal primarily by repressing targets that promote differentiation. In response to differentiation cues, Musashi can switch from a repressor to an activator of target mRNA translation. ...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2019-05-31 | PXD013585 | Pride
Musashi Stem cell Mrna translation Pabp Oocyte 
TranscriptomicsMusashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia
RNA-binding proteins of the Musashi (Msi) family are expressed in stem cell compartments and in aggressive tumors, but they have not yet been widely explored in the blood. Here we demonstrate that Msi2 is the predominant form expressed in hematopoietic stem cells (HSCs), and its knockdown leads to r...
ORGANISM(S): Homo sapiens 
2010-07-11 | E-GEOD-16432 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of differential gene expression of whole testis extracts from transgenic Musashi-2 and transgenic Musashi-1 over-expression mice
Analysis of testis-specific over-expression of Musashi-1 and Musashi-2 at gene expression level. The hypothesis tested in the present study was that testis-specific over-expression of Musashi-1/Musashi-2 would result in differential gene expression profiles from the Wildtype control. Results provide...
ORGANISM(S): Mus musculus 
2014-07-12 | E-GEOD-59358 | biostudies-arrayexpress
ProteomicsCell type-specific control of secondary cell wall formation by Musashi-type translational regulators in Arabidopsis
Deciphering the mechanism of secondary cell wall/SCW formation in vascular plants is key to understanding their development and the molecular basis of biomass recalcitrance. A sophisticated network of transcription factors has been implicated in SCW synthesis in plants, but little is known about the...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2023-09-28 | PXD040207 | Pride
Arabidopsis Musashi-type transcriptional regulator Cell wall Interactomic 
TranscriptomicsMusashi 2 regulates normal hematopoiesis and accelerates leukemogenesis (LK and MS12-inducible)
We demonstrate that Msi2 is the predominant form expressed in hematopoietic stem cells (HSC), and its knockdown leads to reduced engraftment and depletion of HSCs in vivo. Overexpression of Msi2 in a mouse model increases HSC cell cycle progression and cooperates with BCR-ABL1 to induce an aggressiv...
ORGANISM(S): Mus musculus 
2010-07-21 | E-GEOD-22773 | biostudies-arrayexpress
TranscriptomicsMusashi 2 regulates normal hematopoiesis and accelerates leukemogenesis (Leukemia cell lines)
We demonstrate that Msi2 is the predominant form expressed in hematopoietic stem cells (HSC), and its knockdown leads to reduced engraftment and depletion of HSCs in vivo. Overexpression of Msi2 in a mouse model increases HSC cell cycle progression and cooperates with BCR-ABL1 to induce an aggressiv...
ORGANISM(S): Homo sapiens 
2010-07-21 | E-GEOD-22775 | biostudies-arrayexpress
TranscriptomicsMusashi 2 regulates normal hematopoiesis and accelerates leukemogenesis (LSK and LK)
We demonstrate that Msi2 is the predominant form expressed in hematopoietic stem cells (HSC), and its knockdown leads to reduced engraftment and depletion of HSCs in vivo. Overexpression of Msi2 in a mouse model increases HSC cell cycle progression and cooperates with BCR-ABL1 to induce an aggressiv...
ORGANISM(S): Mus musculus 
2010-07-22 | E-GEOD-22774 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of differential gene expression of whole testis extracts from transgenic Musashi-2 and transgenic Musashi-1 over-expression mice
Analysis of testis-specific over-expression of Musashi-1 and Musashi-2 at gene expression level. The hypothesis tested in the present study was that testis-specific over-expression of Musashi-1/Musashi-2 would result in differential gene expression profiles from the Wildtype control. Results provide...
ORGANISM(S): Mus musculus 
2014-07-12 | GSE59358 | GEO
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