Sort   by:  
 Page size 
MetabolomicsZika virus disrupts steroidogenesis and impairs spermatogenesis by stalling the translation of CYP17A1 mRNA

ZIKV infection is associated with testicular damage and abnormal spermatogenesis. However, the molecular mechanisms underlying these pathogenic processes remain unclear. Here, we demonstrate that ZIKV disrupts Leydig cells' ability to produce testosterone, leading to decreased sperm counts and mo...

2025-06-29 | MTBLS12549 | MetaboLights
MetabolomicsAntioxidant Activity, Phytochemical Profiling by UPLC-QTOF-MS, and In Silico Targeting of the RNA-Binding Protein DRBD18 of Trypanosoma brucei by Bioactive Compounds from Tetradenia riparia and Tetracera poggei
Oxidative stress plays a key role in the pathogenesis of African trypanosomiasis, and plant-derived antioxidants represent a promising source of dual-action compounds capable of both scavenging reactive oxygen species and interfering with parasite survival. The present study investigates the antioxi...
2026-09-10 | MTBLS15597 | MetaboLights
ProteomicsYBX3 is a versatile RNA-binding protein that controls amino acid import by regulating SLC mRNA abundance
Summary: Amino acids (AA) support protein synthesis, and thus cell growth and proliferation. Specialized transporters mediate AA exchange across membranes and their regulation is critical for AA homeostasis. Here, we report that the DNA- and RNA-binding protein YBX3 regulates the expression of AA t...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-11-06 | MSV000083108 | MassIVE
ProteomicsmRNA binding - Insights into RNA biology from an atlas of mammalian mRNA-binding proteins
RNA-binding proteins (RBPs) determine RNA fate from synthesis to decay. Employing two complementary protocols for covalent UV crosslinking of RBPs to RNA, we describe a systematic, unbiased, and comprehensive approach, termed "interactome capture," to define the mRNA interactome of proliferating hum...
ORGANISM(S): Homo sapiens (Human) 
2015-09-11 | PXD002880 | Pride
Mrna binding 
OtherInsights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Data from ProteomeXchange, PXD ID: PXD002880. Experiment: KS_A4_3, file: folder summary. Published as part of Cell. 2012 Jun 8;149(6):1393-406 . From the Abstract: {{i}} RNA-binding proteins (RBPs) determine RNA fate from synthesis to decay. Employing two complementary protocols for covalent UV cro...
ORGANISM(S): Homo_sapiens_viruses, Human_female 
GPM11210041750 | GPMDB
Resource Reanalysis 
TranscriptomicsIntegrative regulatory mapping indicates that the RNA-binding protein HuR (ELAVL1) couples pre-mRNA processing and mRNA stability [sequence data]
RNA-binding proteins coordinate the fates of multiple RNAs, but the principles underlying these global interactions remain poorly understood. We elucidated regulatory mechanisms of the RNA-binding protein HuR, by integrating data from diverse high-throughput targeting technologies, specifically PAR-...
ORGANISM(S): Homo sapiens 
2011-08-19 | E-GEOD-29779 | biostudies-arrayexpress
TranscriptomicsPervasive and dynamic protein binding sites of the mRNA transcriptome in Saccharomyces cerevisiae
Protein-RNA interactions are integral components of nearly every aspect of biology including regulation of gene expression, assembly of cellular architectures, and pathogenesis of human diseases. However, studies in the past few decades have only uncovered a small fraction of the vast landscape of t...
ORGANISM(S): Saccharomyces cerevisiae 
2013-01-29 | E-GEOD-43747 | biostudies-arrayexpress
TranscriptomicsPervasive TTP binding but selective target mRNA destabilization in the macrophage transcriptome [RNA-Seq_2]
Precise control of mRNA decay is fundamental for robust yet not exaggerated inflammatory responses to pathogens. Parameters determining the specificity and extent of mRNA degradation within the entire inflammation-associated transcriptome remain incompletely understood. Using transcriptome-wide high...
ORGANISM(S): Mus musculus 
2016-05-17 | E-GEOD-78209 | biostudies-arrayexpress
ProteomicsmRNA-binding proteins of Leishmania donovani LC-MSMS
Leishmania are unicellular eukaryotes responsible for leishmaniasis in humans. Like other trypanosomatids, leishmania regulate protein coding gene expression almost exclusively at the post-transcriptional level with the help of RNA binding proteins (RBPs). Due to the presence of polycystronic trans...
ORGANISM(S): Leishmania donovani 
2017-02-08 | PXD005601 | Pride
Lc-msms Mrna-binding proteins Leishmania donovani Interactome capture 
TranscriptomicsPervasive TTP binding but selective target mRNA destabilization in the macrophage transcriptome [PAR-iCLIP]
Precise control of mRNA decay is fundamental for robust yet not exaggerated inflammatory responses to pathogens. Parameters determining the specificity and extent of mRNA degradation within the entire inflammation-associated transcriptome remain incompletely understood. Using transcriptome-wide high...
ORGANISM(S): Mus musculus 
2016-05-17 | E-GEOD-63466 | biostudies-arrayexpress
Sort   by:  
 Page size