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TranscriptomicsRole of mRNA stability during bacterial adaptation
Bacterial adaptation involves extensive cellular reorganization. In particular, growth rate adjustments are associated with substantial modifications of gene expression and mRNA abundance. In this work we aimed to assess the role of mRNA degradation during such variations. A genome-wide transcript...
ORGANISM(S): Lactococcus lactis 
2014-06-16 | E-GEOD-43875 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of yeast to determine mRNA stability at different time points following mild hyperosmotic shock
Analysis of mRNA stability in S. cerevisiae in connection to hyperosmotic stress at different time points following mild hyperosmotic shock in Saccharomyces cerevisiae cells.
ORGANISM(S): Saccharomyces cerevisiae 
2009-01-22 | E-TABM-622 | biostudies-arrayexpress
ProteomicsThe Parkinson's disease protein alpha-synuclein is a direct modulator of Processing-bodies and mRNA stability
Hallacli E, Kayatekin C, Nazeen S, Wang XH, Sheinkopf Z, Sathyakumar S, Sarkar S, Jiang X, Dong X, Di Maio R, Wang W, Keeney MT, Felsky D, Sandoe J, Vahdatshoar A, Udeshi ND, Mani DR,Carr SA, de Jager P, Myers CL, Lindquist S, Greenmyre TJ, Bartel DP, Feany MB, Sunyaev S, Chung CY and Khurana V. Alp...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-03-09 | MSV000089026 | MassIVE
TranscriptomicsFunctional coordination and HuR-mediated regulation of mRNA stability during T cell activation
We evaluated changes in mRNA stability and transcription using 4sU metabolic pulse labeling across a four hour time course following activation of Jurkat T cells with PMA and PHA Measurement of total mRNA (T) and 4sU labeled mRNA (IP) in three biological replicates at five time points: prior to acti...
ORGANISM(S): Homo sapiens 
2015-10-28 | E-GEOD-71382 | biostudies-arrayexpress
TranscriptomicsIntegrative regulatory mapping indicates that the RNA-binding protein HuR (ELAVL1) couples pre-mRNA processing and mRNA stability [sequence data]
RNA-binding proteins coordinate the fates of multiple RNAs, but the principles underlying these global interactions remain poorly understood. We elucidated regulatory mechanisms of the RNA-binding protein HuR, by integrating data from diverse high-throughput targeting technologies, specifically PAR-...
ORGANISM(S): Homo sapiens 
2011-08-19 | E-GEOD-29779 | biostudies-arrayexpress
TranscriptomicsChanges in mRNA Stability Associated with Cold Stress in Arabidopsis Cells
Control of mRNA half-life is a powerful strategy to adjust individual mRNA levels to various stress conditions, because the mRNA degradation rate controls not only the steady-state mRNA level but also the transition speed of mRNA levels. Here, we analyzed mRNA half-life changes in response to cold s...
ORGANISM(S): Arabidopsis thaliana 
2012-12-16 | E-GEOD-31837 | biostudies-arrayexpress
Transcriptomicsm6A-dependent regulation of messenger RNA stability
N6-methyladenosine (m6A) is the most prevalent internal modification present in the mRNA of all higher eukaryotes. Here we present that m6A is selectively recognized by human YTH domain family (YTHDF2) protein to regulate mRNA degradation. By using crosslinking and immunoprecipitation, we have ident...
ORGANISM(S): Homo sapiens 
2013-11-29 | E-GEOD-49339 | biostudies-arrayexpress
ProteomicsCLOCK regulates Drp1 mRNA stability and mitochondrial homeostasis by interacting with PUF60
This study demonstrated that circadian gene clock plays an important role in the regulation of mitochondrial homeostasis. In this process, CLOCK interacts with PUF60 and affects the mRNA stability of Drp1.
ORGANISM(S): Mus Musculus 
PXD032057 |
TranscriptomicsRegulatory consequences of TARBP2 knock-down in MDA-LM2 cell-line [stability experiment]
siRNA-mediated knock-down followed by transcriptomic profiling revealed that silencing of TARBP2 resulted in a significant increase in the stability of sRSE-carrying transcripts. Two independent siRNAs were used to knock down TARBP2 in metastatic MDA-LM2 cells. The cells were then subjected to whole...
ORGANISM(S): Homo sapiens 
2014-07-24 | E-GEOD-49612 | biostudies-arrayexpress
ProteomicsCHD2 maintains spermatogonial self-renewal by promoting chromatin activity and mRNA stability
Chromodomain Helicase DNA-binding Domain 2 (CHD2), as a chromatin remodeling factor, was shown to be involved in the regulation of gene expression in embryonic development, neurodevelopment and myelopoiesis. However, its role in male germ cell development has not been elucidated. Here, we confirmed ...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD032277 | Pride
Cstf3 Chromatin remodeling Chd2 Spermatogenesis Mrna stability 
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