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TranscriptomicsCOMPARATIVE SYSTEMS TOXICOLOGY ANALYSIS OF CIGARETTE SMOKE AND AEROSOL FROM A CANDIDATE MODIFIED RISK TOBACCO PRODUCT IN ORGANOTYPIC HUMAN GINGIVAL EPITHELIAL CULTURES: A 3-DAY REPEATED EXPOSURE STUDY.
Smoking is one of the major lifestyle-related risk factors for periodontal diseases. Modified risk tobacco products (MRTP) offer a promising alternative in the harm reduction strategy for adult smokers unable to quit. Using a systems toxicology approach, we investigated and compared the exposure eff...
ORGANISM(S): Homo sapiens 
2017-04-01 | E-MTAB-5609 | biostudies-arrayexpress
TranscriptomicsCOMPARATIVE SYSTEMS TOXICOLOGY ANALYSIS OF CIGARETTE SMOKE AND AEROSOL FROM A CANDIDATE MODIFIED RISK TOBACCO PRODUCT IN ORGANOTYPIC HUMAN GINGIVAL EPITHELIAL CULTURES: A 3-DAY REPEATED EXPOSURE STUDY.
Smoking is one of the major lifestyle-related risk factors for periodontal diseases. Modified risk tobacco products (MRTP) offer a promising alternative in the harm reduction strategy for adult smokers unable to quit. Using a systems toxicology approach, we investigated and compared the exposure eff...
ORGANISM(S): Homo sapiens 
2017-04-01 | E-MTAB-5608 | biostudies-arrayexpress
TranscriptomicsA Six-Month Systems Toxicology Inhalation/Cessation Study in ApoE-/- Mice to Investigate Cardiovascular and Respiratory Exposure Effects of Modified Risk Tobacco Products, CHTP 1.2 and THS 2.2, Compared with Conventional Cigarettes (miRNA data)
Smoking is one of the major modifiable risk factors in the development and progression of chronic obstructive pulmonary disease (COPD) and cardiovascular disease (CVD). Modified-risk tobacco products (MRTP) are being developed to provide substitute products for smokers who are unable or unwilling t...
ORGANISM(S): Mus musculus 
2019-04-18 | E-MTAB-7892 | biostudies-arrayexpress
TranscriptomicsA Six-Month Systems Toxicology Inhalation/Cessation Study in ApoE-/- Mice to Investigate Cardiovascular and Respiratory Exposure Effects of Modified Risk Tobacco Products, CHTP 1.2 and THS 2.2, Compared with Conventional Cigarettes
Smoking is one of the major modifiable risk factors in the development and progression of chronic obstructive pulmonary disease (COPD) and cardiovascular disease (CVD). Modified-risk tobacco products (MRTP) are being developed to provide substitute products for smokers who are unable or unwilling t...
ORGANISM(S): Mus musculus 
2019-04-18 | E-MTAB-7444 | biostudies-arrayexpress
TranscriptomicsAssessment of the impact of aerosol from a potential modified risk tobacco product compared with cigarette smoke on human organotypic oral epithelial cultures under different exposure regimens (buccal epithelial cells-mRNA dataset)
Cigarette smoke (CS) is affecting considerably the oral mucosa. Heating, instead of burning, tobacco reduces consistently the amount of toxic compounds and may exert a lower impact on oral health than combusted cigarettes. The carbon-heated tobacco product 1.2 (CHTP1.2) is a potential modified risk ...
ORGANISM(S): Homo sapiens 
2018-03-07 | E-MTAB-6542 | biostudies-arrayexpress
TranscriptomicsAssessment of the impact of aerosol from a potential modified risk tobacco product compared with cigarette smoke on human organotypic oral epithelial cultures under different exposure regimens (gingival epithelial cells-mRNA dataset)
Cigarette smoke (CS) is affecting considerably the oral mucosa. Heating, instead of burning, tobacco reduces consistently the amount of toxic compounds and may exert a lower impact on oral health than combusted cigarettes. The carbon-heated tobacco product 1.2 (CHTP1.2) is a potential modified risk ...
ORGANISM(S): Homo sapiens 
2018-03-07 | E-MTAB-6537 | biostudies-arrayexpress
TranscriptomicsAssessment of the impact of aerosol from a potential modified risk tobacco product compared with cigarette smoke on human organotypic oral epithelial cultures under different exposure regimens (buccal epithelial cells-microRNA dataset)
Cigarette smoke (CS) is affecting considerably the oral mucosa. Heating, instead of burning, tobacco reduces consistently the amount of toxic compounds and may exert a lower impact on oral health than combusted cigarettes. The carbon-heated tobacco product 1.2 (CHTP1.2) is a potential modified risk ...
ORGANISM(S): Homo sapiens 
2018-03-07 | E-MTAB-6543 | biostudies-arrayexpress
TranscriptomicsAssessment of the impact of aerosol from a potential modified risk tobacco product compared with cigarette smoke on human organotypic oral epithelial cultures under different exposure regimens (gingival epithelial cells-microRNA dataset).
Cigarette smoke (CS) is affecting considerably the oral mucosa. Heating, instead of burning, tobacco reduces consistently the amount of toxic compounds and may exert a lower impact on oral health than combusted cigarettes. The carbon-heated tobacco product 1.2 (CHTP1.2) is a potential modified risk ...
ORGANISM(S): Homo sapiens 
2018-03-07 | E-MTAB-6538 | biostudies-arrayexpress
TranscriptomicsEvaluation of the Tobacco Heating System 2.2 (THS2.2). Part 5: microRNA expression from a 90-day rat inhalation study indicates that exposure to THS 2.2 aerosol causes reduced effects on lung tissue compared with cigarette smoke
Modified-risk tobacco products (MRTP) are designed to reduce the individual risk of tobacco-related disease as well as population harm compared to smoking cigarettes. Experimental proof of their benefit needs to be provided at multiple levels in research fields. Here, we examined microRNA (miRNA) le...
ORGANISM(S): Rattus norvegicus 
2016-11-30 | E-MTAB-5296 | biostudies-arrayexpress
TranscriptomicsIn-Vitro Cell Adhesion Assay
Alterations of endothelial adhesive properties by cigarette smoke (CS) can progressively favor the development of atherosclerosis which may cause cardiovascular disorders. Modified risk tobacco products (MRTPs) are tobacco products scientifically validated to reduce smoking-related health risks. A s...
ORGANISM(S): Homo sapiens 
2016-01-04 | E-MTAB-3923 | biostudies-arrayexpress
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