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ITD mutations in the FLT3 gene occur in the 30% of acute myeloid leukemia patients. The integration of ITD in the tyrosine kinase domain (TKD-ITD) of the FLT3 receptor has been shown to confer resistance to standard chemotherapy treatment. We applied state-of-the-art, high-sensitive, mass spectromet...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-20 | PXD038638 | Pride
Acute myeloid leukemia (AML) is a hematological cancer that affects mainly the elderly. Although complete remission (CR) is achieved for the majority of the patients after induction and consolidation therapies, nearly two-thirds relapse within a short interval. Therefore, understanding of the biolog...
ORGANISM(S): Homo sapiens (Human) 
2020-04-14 | PXD014997 | Pride
A phosphoproteomic analysis of heat shock response in the mammalian infective bloodstream form Trypanosoma brucei was conducted using SILAC-based quantitation. Treatment at 41 0C for 1h produced significantly altered phosphorylation at 193 sites and significantly altered the abundance of 20 proteins...
ORGANISM(S): Trypanosoma brucei 
2020-03-31 | PXD016482 | Pride
Clematis terniflora DC. is used as traditional herb medicine since ancient China. The active substances in C.terniflora have been confirmed to be effective in treating disease like prostatitis. The UV light radiation is a common environmental factor that damage the plants and has an influence on the...
ORGANISM(S): Clematis terniflora (Sweet autumn clematis) 
2023-03-11 | PXD038136 | Pride
A central goal of modern biology is to understand the molecular basis of phenotype evolution between species. Previously, the evolutionary profiling at the molecular level has been largely limited to the nucleotide level. Nevertheless, the genotype is translated to proteotype through comprehensive a...
ORGANISM(S): Bos taurus (Bovine) Sus scrofa (Pig) Homo sapiens (Human) Oryctolagus cuniculus (Rabbit) Canis lupus Monodelphis domestica Felis catus (Cat) (Felis silvestris catus) Rattus norvegicus (Rat) Ovis aries Macaca mulatta (Rhesus macaque) Equus caballus (Horse) 
2022-09-22 | PXD028979 | Pride
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