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To assess changes in protein expression levels following loss of MST3/4, we co-depleted MST3 and MST4 and quantified the changes in total protein levels by using SILAC.
ORGANISM(S): Homo sapiens (Human) 
2022-02-28 | PXD006168 | Pride
Mammalian STE20-like protein kinases 3 and 4 (MST3/4) have recently emerged as crucial regulators of several key cellular processes such as proliferation, migration, and polarity. However, the downstream target pathways which are regulated by the kinase activity of MST3/4 remain poorly characterised...
ORGANISM(S): Homo sapiens (Human) 
2022-02-28 | PXD006167 | Pride
ROS-induced cytosolic release of PGAM5 accelerates cancer progression via MST3-YAP axis
Mesenchymal SLMAP coordinates with MST3 to govern gut elongation during development
Mesenchymal SLMAP coordinates with MST3 to govern gut elongation during development [RNAseq_TL]
ROS-induced cytosolic release of mitochondrial PGAM5 accelerates colorectal cancer progression via MST3-mediated YAP activation
Mesenchymal SLMAP coordinates with MST3 to govern gut elongation during development (scRNA-Seq)
Aberrant mtROS release in response to mitochondrial stress are considered to be a major novel feature of neoplastic transformation. However, the molecular mechanisms by which mtROS contribute to CRC development have not been fully elucidated. In this study, we showed that upon sensing the mtROS sign...
ORGANISM(S): Mus musculus 
2024-11-05 | GSE248431 | GEO
Developing gut in mice undergoes rapid elongation during late embryogenesis, yet significantly slows down after birth. Precise regulatory mechanism of this dynamic morphogenetic process remains unknown. Utilizing scRNA-seq analysis, we show that YAP activity in Cxcl13high intestinal fibroblasts is t...
ORGANISM(S): Mus musculus 
2025-06-16 | GSE276611 | GEO
Developing gut in mice undergoes rapid elongation during late embryogenesis, yet significantly slows down after birth. Precise regulatory mechanism of this dynamic morphogenetic process remains unknown. Utilizing scRNA-seq analysis, we show that YAP activity in Cxcl13high intestinal fibroblasts is t...
ORGANISM(S): Mus musculus 
2025-06-16 | GSE276668 | GEO
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