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TranscriptomicsExpression data from C2C12 murine myoblast cells infected with an inducible Msx1-ER fusion protein
The spatial and temporal control of gene expression during development requires the concerted actions of sequence-specific transcriptional regulators and epigenetic chromatin modifiers, which are thought to function within precise nuclear compartments. However, how these activities are coordinated w...
ORGANISM(S): Mus musculus 
2011-08-16 | E-GEOD-26021 | biostudies-arrayexpress
GenomicsMsx1 ChIP-Seq from C2C12 murine myoblast cells expressing Flag-Msx1 protein
The spatial and temporal control of gene expression during development requires the concerted actions of sequence-specific transcriptional regulators and epigenetic chromatin modifiers, which are thought to function within precise nuclear compartments. However, how these activities are coordinated w...
ORGANISM(S): Mus musculus 
2011-08-17 | E-GEOD-26711 | biostudies-arrayexpress
ProteomicsGlobal quantitative proteomics analysis reveals the downstream signaling networks of Msx1 and Msx2 in skeletal muscle development
The homeoprotein Msx1 and Msx2 involved in normal skeletal muscle development and also contribute to muscle defects if altered during development. Deciphering the downstream signaling networks of Msx1 and Msx2 in myoblasts differentiation will help us to understand the molecular events that contribu...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-20 | PXD026944 | Pride
Skeletal muscle differentiation Msx2 Msx1 Quantitative proteomics 
TranscriptomicsTranscription profiling by array of human colorectal cancer SW620 cells upon MSX1 depletion.
The first step in the development of human colorectal cancer (CRC) is the aberrant hyperactivation of the Wnt signaling pathway, predominantly caused by inactivating mutations in the adenomatous polyposis coli (APC) gene encoding an essential tumor suppressor. In order to identify genes affected by ...
ORGANISM(S): Homo sapiens 
2019-11-01 | E-MTAB-6928 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of Apc-deficient mouse small intestinal epithelium upon Msx1 depletion.
The first step in the development of human colorectal cancer is the aberrant hyperactivation of the Wnt signaling pathway, predominantly caused by inactivating mutations in the adenomatous polyposis coli (Apc) gene encoding an essential tumor suppressor. The gene encoding transcriptional factor msh ...
ORGANISM(S): Mus musculus 
2019-11-01 | E-MTAB-6930 | biostudies-arrayexpress
TranscriptomicsIntegrated bioinformatic and wet-lab approach to identify potential oncogenic networks in neuroblastoma: MSX1
mRNA profiles of thousands of human tumors are available, but methods to deduce oncogenic signaling networks from these data lag behind. It is especially challenging to identify main-regulatory routes, and to generalize conclusions obtained from experimental models. We designed the bioinformatic pla...
ORGANISM(S): Homo sapiens 
2014-05-28 | E-GEOD-16481 | biostudies-arrayexpress
GenomicsAcetylation-Triggered Degradation of MSX1 Impairs Palatal Development
Acetylation-Triggered Degradation of MSX1 Impairs Palatal Development
PRJNA1403284 | ENA
GenomicsPRMT1-methylated MSX1 phase separates to control palate development
PRMT1-methylated MSX1 phase separates to control palate development
PRJNA1205740 | ENA
TranscriptomicsTranscription profiling of human neuroblastoma cell line expressing PHOX2B
Neuroblastoma is an embryonal tumour of the peripheral sympathetic nervous system (SNS). One of the master regulator genes for peripheral SNS differentiation, the homeobox transcription factor PHOX2B, is mutated in familiar and sporadic neuroblastomas. Here we report that inducible expression of PH...
ORGANISM(S): Homo sapiens 
2008-10-26 | E-GEOD-9339 | biostudies-arrayexpress
TranscriptomicsEpigenetic regulation of the homeobox gene MSX1 associates with platinum resistant disease in high grade serous epithelial ovarian cancer
Introduction: Although High Grade Serous Ovarian Cancer (HGSOC) is considered a chemo-responsive disease, a proportion of patients do not respond to platinum-based chemotherapy at presentation or have progression-free survival of <6 months. Validated biomarkers of lack of response would enable alter...
ORGANISM(S): Homo sapiens 
2015-11-26 | E-GEOD-75414 | biostudies-arrayexpress
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