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ProteomicsAutophagy lipidation machinery regulates microtubule dynamics to maintain axonal homeostasis
Axon integrity is crucial for neuronal function. To maintain axonal homeostasis neurons have evolved a unique organization of the microtubule (MT) cytoskeleton, which supports axonal morphology and provides tracks for intracellular transport. Although abnormal MT-based trafficking highlights the pat...
ORGANISM(S): Mus musculus (Mouse) 
2020-03-25 | PXD011279 | Pride
Microtubule dynamics Neuron Autophagy Lc3 Axonal homoeostasis 
TranscriptomicsMT-targeted MT1/2 orchestrates mitochondrial fusion dynamics-mediated WNT/β-catenin signaling to promote DA neuronal differentiation of human iPS and nerve regeneration in PD mice
Parkinson's disease (PD) is a challenging neurodegenerative disorder. Recently, therapy of neural stem cells (NSCs) derived from human induced pluripotent stem cells (hiPSCs) has emerged as a significant advancement in regenerative medicine. Melatonin (MT), acting as a mitochondrial targeting hormon...
ORGANISM(S): Homo sapiens 
2026-01-14 | GSE295508 | GEO
UnknownRegulation of MT dynamics via direct binding of an Abl family kinase.
Not available
S-EPMC6891085 | biostudies-literature
TranscriptomicsTranscriptome dynamics during fruit development of sweet orange (Citrus sinensis)
• To dissect how the genes are dynamically and differentially expressed during fruit development in sweet orange, a comprehensive transcriptomic study was performed in a pleiotropic mutant (MT) and its wild type (WT). • The detection of the fruit transcriptomic changes was conducted at five stages ...
ORGANISM(S): Citrus sinensis 
2012-06-22 | E-GEOD-22505 | biostudies-arrayexpress
GenomicsMT-targeted MT1/2 orchestrates mitochondrial fusion dynamics-mediated WNT/β-catenin signaling to promote DA neuronal differentiation of human iPS and nerve regeneration in PD mice
MT-targeted MT1/2 orchestrates mitochondrial fusion dynamics-mediated WNT/β-catenin signaling to promote DA neuronal differentiation of human iPS and nerve regeneration in PD mice
PRJNA1255076 | ENA
UnknownMicrobial communities in glacial lakes of Glacier National Park, MT, USA.
Not available
S-EPMC12199700 | biostudies-literature
UnknownSensory integration dynamics in a hierarchical network explains choice probabilities in cortical area MT.
Not available
S-EPMC4347303 | biostudies-literature
ProteomicsCentrosomal ALIX regulates mitotic spindle orientation by modulating astral microtubule dynamics
The orientation of the mitotic spindle (MS) is tightly regulated, but the molecular mechanisms are incompletely understood. Here we report a novel role for the multifunctional adaptor protein ALG-2-interacting protein X (ALIX) in regulating MS orientation in addition to its well-established role in ...
ORGANISM(S): Homo sapiens (Human) 
2018-06-04 | PXD009747 | Pride
Mitotic spindle orientation Alix Microtubule G-tubulin Map1s 
UnknownElucidating the Basis for Permissivity of the MT-4 T-Cell Line to Replication of an HIV-1 Mutant Lacking the gp41 Cytoplasmic Tail.
Not available
S-EPMC7654282 | biostudies-literature
UnknownThreshold of heteroplasmic truncating MT-ATP6 mutation in reprogramming, Notch hyperactivation and motor neuron metabolism.
Not available
S-EPMC8947243 | biostudies-literature
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