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ProteomicsA revised molecular model of ovarian cancer biomarker CA125 (MUC16) enabled by long-read sequencing
The biomarker CA125, a peptide epitope located in several tandem repeats of the mucin MUC16, is the gold-standard for monitoring regression and recurrence of high-grade serous ovarian cancer in response to therapy. However, the CA125 epitope along with several structural features of the MUC16 molecu...
ORGANISM(S): Homo sapiens (Human) 
2024-05-21 | PXD044117 | Pride
Proteomics Ovarian cancer Ca125 Biomarker Muc16 Nanopore sequencing 
ProteomicsImmunoaffinity-free chromatographic purification of ovarian cancer biomarker CA125 (MUC16) from blood serum
The present work developed a non-affinity-based chromatographic method to enrich MUC16 from serum. The enriched MUC16 sample was further processed using a Midi Top 14 abundant protein depletion column. Peptides identified using bottom-up proteomics yielded 1–8% coverage of MUC16. Additionally, MUC16...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD053289 | Pride
Human Plasma Ovarian Muc16 Ca125 
ProteomicsLoss of ST8SIA6 Promotes Colorectal Cancer Metastasis by Enhancing MUC16-Integrin β4 Signaling
This project investigates the functional role of the α2,8-sialyltransferase ST8SIA6 in the progression and metastasis of colorectal cancer. Through the use of Siglec-7-based enrichment and subsequent mass spectrometry analysis, MUC16 was identified as a primary glycoprotein affected by the loss of S...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD077963 | Pride
Colorectal cancer  metastasis  st8sia6  muc16  integrin β4  glycosylation  src/fak signaling 
TranscriptomicsTranscription profiling time series of a human conjunctival epithelial cell line treated with retinoic acid
Purpose. How vitamin A contributes to the maintenance of the wet-surfaced phenotype at the ocular surface is not well understood. We sought to identify vitamin A responsive genes in ocular surface epithelia using gene microarray analysis of cultures of a human conjunctival epithelial cell line (HCjE...
ORGANISM(S): Homo sapiens 
2007-12-12 | E-GEOD-2835 | biostudies-arrayexpress
GenomicsInfluence of the MUC16 on gene expression of cancer cells from PDAC
Influence of the MUC16 on gene expression of cancer cells from PDAC
PRJNA1040129 | ENA
GenomicsInfluence of the anti-MUC16 humanized monoclonal antibody AR9.6 on gene expression in MUC16 expressing cancer cells in patient-derived organoids
Influence of the anti-MUC16 humanized monoclonal antibody AR9.6 on gene expression in MUC16 expressing cancer cells in patient-derived organoids
PRJNA960655 | ENA
TranscriptomicsMUC16 is a critical molecule for the pancreatic tumor microenvironment and metastasis in PDAC
Investigate the cooperative action of MUC16 with other defined oncogenic mutations in the metastasis of PC using Muc16–/– mice
ORGANISM(S): Mus musculus 
2022-10-22 | GSE212777 | GEO
TranscriptomicsInfluence of the MUC16 on gene expression of cancer cells from PDAC
To investigate the differentially expressed genes and the pathways they might alter upon loss of MUC16 and subsequent perturbation of its downstream signaling We performed gene expression profiling analysis using data obtained from RNA-seq of the two different conditions (WT versus MUC16-knockout) (...
ORGANISM(S): Homo sapiens 
2024-11-30 | GSE247666 | GEO
UnknownOverexpression of MUC16 predicts favourable prognosis in MUC16-mutant cervical cancer related to immune response.
Not available
S-EPMC7388571 | biostudies-literature
TranscriptomicsMechanism of lacritin-dependent production of the important dry eye mucin 'MUC16'
Lacritin targets its coreceptor 'syndecan-1' in lacritin-dependent production of the important dry eye mucin 'MUC16'. Real-time PCR analysis suggests that this effect is post-transcriptional. In contrast, serum stimulation of MUC16 by these cells is transcriptionally dependent. Our goal is to determ...
ORGANISM(S): Homo sapiens 
2011-09-06 | GSE31930 | GEO
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