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TranscriptomicsApoptosis enhancing drugs overcome innate platinum resistance in CA125 negative tumor initiating populations of high grade serous ovarian cancer
High grade serous ovarian cancers (HGSC) are deadly malignancies that relapse despite carboplatin chemotherapy. Here we show that 16 independent primary HGSCs contain a CA125 negative population enriched for carboplatin resistant cancer initiating cells. Transcriptome analysis reveals up-regulation ...
ORGANISM(S): Homo sapiens 
2015-08-01 | E-GEOD-70072 | biostudies-arrayexpress
ProteomicsA revised molecular model of ovarian cancer biomarker CA125 (MUC16) enabled by long-read sequencing
The biomarker CA125, a peptide epitope located in several tandem repeats of the mucin MUC16, is the gold-standard for monitoring regression and recurrence of high-grade serous ovarian cancer in response to therapy. However, the CA125 epitope along with several structural features of the MUC16 molecu...
ORGANISM(S): Homo sapiens (Human) 
2024-05-21 | PXD044117 | Pride
Proteomics Ovarian cancer Ca125 Biomarker Muc16 Nanopore sequencing 
ProteomicsImmunoaffinity-free chromatographic purification of ovarian cancer biomarker CA125 (MUC16) from blood serum
The present work developed a non-affinity-based chromatographic method to enrich MUC16 from serum. The enriched MUC16 sample was further processed using a Midi Top 14 abundant protein depletion column. Peptides identified using bottom-up proteomics yielded 1–8% coverage of MUC16. Additionally, MUC16...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD053289 | Pride
Human Plasma Ovarian Muc16 Ca125 
Genomics
Genetic variants that influence CA125
PRJNA1327853 | ENA
TranscriptomicsApoptosis enhancing drugs overcome innate platinum resistance in CA125 negative tumor initiating populations of high grade serous ovarian cancer
High grade serous ovarian cancers (HGSC) are deadly malignancies that relapse despite carboplatin chemotherapy. Here we show that 16 independent primary HGSCs contain a CA125 negative population enriched for carboplatin resistant cancer initiating cells. Transcriptome analysis reveals up-regulation ...
ORGANISM(S): Homo sapiens 
2015-08-01 | GSE70072 | GEO
UnknownCA125-Tn ELISA assay improves specificity of pre-operative diagnosis of ovarian cancer among patients with elevated serum CA125 levels.
Not available
S-EPMC8246179 | biostudies-literature
UnknownExploring the glycosylation of serum CA125.
Not available
S-EPMC3759877 | biostudies-literature
UnknownPredicting Circulating CA125 Levels among Healthy Premenopausal Women.
Not available
S-EPMC6548604 | biostudies-literature
UnknownA binding domain on mesothelin for CA125/MUC16.
Not available
S-EPMC2635045 | biostudies-literature
UnknownCombined magnetic resonance imaging with serum CA125 for dysmenorrhea in adenomyosis.
Not available
S-EPMC12660971 | biostudies-literature
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