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ProteomicsProteomics of Muc17-deficient mice small intestine epithelial cells
To evaluate the impact of Muc17 deletion on other major intestinal mucins, we employed proteomic analysis of isolated Si5 epithelial cells fromMuc17fl/fl and Muc17∆IEC cohoused littermates. Deletion of Muc17 did not result in a compensatory change in the abundance of the gel-forming mucin Muc2 and m...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD048896 | Pride
Muc17  muc3  small intestine  epithelial cells  lfq 
ProteomicsIL-22 promotes postnatal formation of MUC17 glycocalyx barrier that protects host enterocytes
The apical aspects of absorptive epithelial cells form a highly organized brush border membrane (BBM), shaped by densely packed microvilli that are coated with a glycocalyx. Here, we present evidence showing that the glycocalyx forms an epithelial barrier that prevents exogenous molecules from gaini...
ORGANISM(S): Mus musculus (Mouse) 
2021-02-16 | PXD018592 | Pride
Innate immunity Mucin Intestine Microvilli Enterocyte Muc13 Microbiota Muc17 Glycocalyx 
UnknownDNA methylation and histone H3-K9 modifications contribute to MUC17 expression.
Not available
S-EPMC3010767 | biostudies-literature
GenomicsIL-22 promotes formation of MUC17 glycocalyx barrier in postnatal small intestine during weaning
IL-22 promotes formation of MUC17 glycocalyx barrier in postnatal small intestine during weaning
PRJNA691174 | ENA
UnknownCAR-T cell therapy targeting MUC17 in gastric tumors.
Not available
S-EPMC12636950 | biostudies-literature
TranscriptomicsIL-22 promotes formation of MUC17 glycocalyx barrier in postnatal small intestine during weaning
The intestine is under constant exposure to chemicals, antigens and microorganisms from the external environment. Apical aspects of absorptive epithelial cells form a brush border membrane (BBM), shaped by packed microvilli coated with a dense glycocalyx. We present evidence showing that the glycoca...
ORGANISM(S): Mus musculus 
2021-02-16 | GSE164552 | GEO
UnknownThe human transmembrane mucin MUC17 responds to TNFα by increased presentation at the plasma membrane.
Not available
S-EPMC6705488 | biostudies-literature
UnknownMUC17 is an essential small intestinal glycocalyx component that is disrupted in Crohn's disease.
Not available
S-EPMC10888976 | biostudies-literature
UnknownGenetic variations of MUC17 are associated with endometriosis development and related infertility.
Not available
S-EPMC4593232 | biostudies-literature
UnknownMUC17 is an essential small intestinal glycocalyx component that is disrupted in Crohn's disease.
Not available
S-EPMC11948581 | biostudies-literature
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