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ProteomicsRat colon LC-MSMS - Intake of Fish Oil Specifically Modulates Colonic Muc2 Expression in Middle-Aged Rats by Suppressing the Glycosylation Process
Dietary fats have been shown to affect gut microbiota composition and aging gene transcription of middle-aged rats at a normal dose, but little is known about such an effect on gut barrier. In colon, the main component of mucus layer is Muc2, produced by the goblet cells. This study investigated the...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-01-02 | PXD007229 | Pride
Lc-msms Rat Colon 
UnknownIntake of Fish Oil Specifically Modulates Colonic Muc2 Expression in Middle-Aged Rats by Suppressing the Glycosylation Process.
Not available
S-EPMC6120138 | biostudies-literature
UnknownIntestinal Muc2 mucin O-glycosylation is affected by microbiota and regulated by differential expression of glycosyltranferases.
Not available
S-EPMC5444243 | biostudies-literature
UnknownSite-specific O-glycosylation on the MUC2 mucin protein inhibits cleavage by the Porphyromonas gingivalis secreted cysteine protease (RgpB).
Not available
S-EPMC3656315 | biostudies-literature
ProteomicsDegradation of the intestinal mucus layer by the ETEC protease EatA is species specific determined by the structure of the MUC2 mucin
Enterotoxigenic Escherichia coli (ETEC) infections are a leading cause of diarrheal illness, responsible for an estimated 100,000 deaths annually. ETEC pathogenesis is driven by various virulence factors, including toxins, adhesins, and noncanonical factors such as the protease EatA. The first line ...
ORGANISM(S): Escherichia coli ETEC H10407 Homo sapiens (Human) 
2026-01-19 | PXD068558 | Pride
Mucus Mucin o-glycosylation Protease Etec 
UnknownDetailed O-glycomics of the Muc2 mucin from colon of wild-type, core 1- and core 3-transferase-deficient mice highlights differences compared with human MUC2.
Not available
S-EPMC3382349 | biostudies-literature
UnknownMuc2 mucin O-glycosylation interacts with enteropathogenic Escherichia coli to influence the development of ulcerative colitis based on the NF-kB signaling pathway.
Not available
S-EPMC10631195 | biostudies-literature
ProteomicsTrans-Golgi protein TVP23B regulates host-microbe interactions via Paneth cell homeostasis and Goblet cell glycosylation
A key feature in intestinal immunity is the dynamic intestinal barrier, which separates the host from resident and pathogenic microbiota through a mucus gel impregnated with antimicrobial peptides. The mechanisms underlying the maintenance and function of this intestinal barrier are not completely ...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-20 | PXD038895 | Pride
Glycosylation N-ethyl-n-nitrosourea (enu) Inflammatory bowel disease (ibd) Goblet cel Paneth cell Dextran sodium sulfate (dss) 
ProteomicsMembrane proteomis profile along human colon
The colonic epithelium is a highly dynamic system important for regulation of ion and water homeostasis via absorption and secretion, and in maintaining a protective barrier between the outer milieu and the inside of our body. These processes are known to gradually change along the length of the col...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-03-07 | MSV000079561 | MassIVE
UnknownCloning, annotation and developmental expression of the chicken intestinal MUC2 gene.
Not available
S-EPMC3549977 | biostudies-literature
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