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TranscriptomicsTranscription profiling of mouse SNF5 liver-specific inactivation in SNF5 flox/knockouts
Effect of liver-specific inactivation of SNF5 on liver transcriptome. Comparison of control and mutant livers.
ORGANISM(S): Mus musculus 
2005-12-19 | E-MEXP-241 | biostudies-arrayexpress
UnknownThe SWI/SNF chromatin-remodeling complex subunit SNF5 is essential for hepatocyte differentiation.
Not available
S-EPMC1224692 | biostudies-literature
TranscriptomicsHP1, H3-K27me3, and H3-K9me3 Cut & Tag of Het (Cbx1+/+, Cbx3+/+, Cbx5+/-) and TKO (Cbx1-/-, Cbx3-/-, Cbx5-/-) bipotential mouse embryonic liver (BMEL) cells
Cut & Tag was used to localize the 3 mouse HP1 proteins (Cbx1,Cbx3,Cbx5) to the genome of BMEL (bipotential mouse embryonic liver) cells. Het BMEL cells are Cbx1+/+, Cbx3+/+, Cbx5+/- HP1-TKO (triple knock-out cells) are Cbx1-/-, Cbx3-/-, Cbx5-/-. The HP1_TKO cells were used to verify the specificity...
ORGANISM(S): Mus musculus 
2025-06-14 | E-MTAB-15189 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Caco-2 intestinal epithelial cell line infected with wild type Shigella flexneri and a OspF mutantt reveals an injected bacterial effector targets chromatin access for NF-kB as a strategy to shape transcription of immune genes
Phosphorylation of histone H3 at Serine 10 emerges as a mechanism increasing chromatin accessibility of the transcription factor NF-kB for a particular set of immune genes. Here we report that a bacterial pathogen uses this strategy to shape the transcriptional response of infected host cells. We id...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6082 | biostudies-arrayexpress
TranscriptomicsHP1gamma Knock Down in Human cells
Study of HP1 Knock Down on gene expression and splicing regulation in Human HeLa cells Maturation of pre-mRNAs is initiated co-transcriptionally. It is therefore conceivable that chromatin-borne information participates in alternative splicing. Here, we find that elevated levels of tri-methylation o...
ORGANISM(S): Homo sapiens 
2011-02-27 | E-GEOD-25282 | biostudies-arrayexpress
TranscriptomicsImpact of HP1gamma and HP1gamma S83 phosphorylation on the transcriptionnal effect of PMA stimulation of mouse fibroblasts
We have here followed the transcriptional effect of stimulation with the phorbol ester PMA in mouse fibroblasts from HP1gamma null mice recomplemented with either wild-type HP1gamma or an HP1g with an S83A mutation Spontaneously immortalized mouse embryonic fibroblasts from HP1gamma null mice were u...
ORGANISM(S): Mus musculus 
2014-11-01 | E-GEOD-60283 | biostudies-arrayexpress
TranscriptomicsExon array expression profiling: DYRK1A acts as transcriptional activator
Transcriptome analysis of depletion of DYRK1A in HeLa cells Global gene expression profiling has shown upregulation of many genes in the context of DYRK1A depletion in HeLa cells. Many of these genes deregulated by DYRK1A are involved in immune response system. Transcriptome analysis of siRNA agains...
ORGANISM(S): Homo sapiens 
2014-05-01 | E-GEOD-43259 | biostudies-arrayexpress
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