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MetabolomicsOral administration of low-molecular-weight heparin ameliorates colitis by enhancing the gut mucus barrier via microbial tryptophan metabolites

Background and Purpose: Previous studies have reported that oral low molecular weight heparin (LMWH) ameliorated colitis by undefined mechanisms in ulcerative colitis (UC) patients. Our study explored the mechanisms of LMWH on colitis from the perspective of gut microbiota and its metabolites.

2025-10-12 | MTBLS5770 | MetaboLights
TranscriptomicsMicrobiota facilitates dietary heme-induced epithelial hyperproliferation and hyperplasia by breaking the mucus barrier
Colorectal cancer risk is associated with diets high in red meat. Heme, the pigment of red meat, induces cytotoxicity of colonic contents and elicits epithelial damage and compensatory hyperproliferation, leading to hyperplasia. Here we explore the possible causal role of the gut microbiota in heme-...
ORGANISM(S): Mus musculus 
2015-08-03 | E-GEOD-40670 | biostudies-arrayexpress
TranscriptomicsThe protein disulfide isomerase AGR2 is essential for the production of intestinal mucus
Protein disulfide isomerases (PDIs) aid protein folding and assembly by catalyzing formation and shuffling of cysteine disulfide bonds in the endoplasmic reticulum (ER). Many members of the PDI family are expressed in mammals but the roles of specific PDIs in vivo are poorly understood. A recent hom...
ORGANISM(S): Mus musculus 
2010-05-19 | E-GEOD-12503 | biostudies-arrayexpress
ProteomicsTransglutaminase 3 crosslinks MUC2 and stabilizes the colonic mucus layer
Mucus/MUC2 from TGM3-deficient mice is less cross-linked with isopeptide-bond cross-links compared to Mucus/MUC2 from WT mice. This results in protease-labile MUC2-molecules that become degraded in the colonic lumen
ORGANISM(S): Mus musculus (Mouse) 
2022-02-09 | PXD029071 | Pride
Muc2 Transglutaminase Mucus 
GenomicsMucus layer microbiota of Cassiopea xamachana
Mucus layer microbiota of Cassiopea xamachana Targeted loci environmental
PRJNA810909 | ENA
ProteomicsMuc2-dependent microbial colonization of the jejunal mucus layer is diet sensitive and confers resistance to enteric pathogen infection
Obesity is associated with an increased risk of mucosal infections; however, the mechanistic basis of this phenomenon remains incompletely defined. Intestinal mucus barrier systems normally prevent infections, but are sensitive to changes in the luminal environment. Here we demonstrate that mice exp...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-12 | PXD028613 | Pride
Proteomics Q-exactive Obesity Mucus Mouse 
ProteomicsThe gut microbiota affects the mucus barrier
Two C57BL/6 mice colonies maintained in two rooms in the same specific pathogen free (SPF) facility were found to have different gut microbiota and a mucus phenotype specific for each colony. The thickness and growth of the colon mucus was similar in the two colonies, but one colony had mucus not pe...
ORGANISM(S): Mus musculus (Mouse) 
2015-02-09 | PXD001479 | Pride
Microbiota Mucus Colon Ileum 
ProteomicsMucus production, host-microbiome interactions, hormone sensitivity, and innate immune responses modeled in human endo- and ecto-cervix chips
Modulation of mucus production by the human ecto- and endo-cervical epithelium by steroid hormones and associated interactions with commensal microbiome play a central role in the physiology and pathophysiology of the female reproductive tract. However, most of our knowledge about these interactions...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-04-26 | MSV000091806 | MassIVE
TranscriptomicsTranscription profiling of E. coli grown on minimal mucus or minimal glucose
E.coli grown on mucus vs. glucose in shaking cultures
ORGANISM(S): Escherichia coli 
2007-07-27 | E-MEXP-1177 | biostudies-arrayexpress
TranscriptomicsCarbon nutrition of pathogenic and commensal E. coli
Transcriptome profiling of E. coli MG1655, E. coli EDL933, E. coli ECOR26, and E. coli Nissle 1917 grown on mouse cecal mucus as carbon source The carbon sources that support growth of pathogenic E. coli O157:H7 in the mammalian intestine have not previously been investigated. In vivo, pathogenic E...
ORGANISM(S): Escherichia coli 
2008-04-25 | E-GEOD-11254 | biostudies-arrayexpress
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