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This project investigated proline hydroxylation of ChREBP. Proline hydroxylation was investigated in flag-IP enriched protein extracts from ChREBP-flag overexpressing HEK293 cells (A) and in ChREBP-IP enriched mouse liver protein (male, C57BL6/J) (B).
ORGANISM(S): Mus musculus (Mouse) 
2020-10-19 | PXD019137 | Pride
Gene expression varies between individuals and corresponds to a key step linking genotypes to phenotypes. Regulation of transcript and protein abundances can affect the final phenotypes and has been related to many human diseases. However, our knowledge regarding the species-wide genetic control of ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-04-30 | PXD044523 | Pride
Telomeric sequences vary across the tree of life and intimately co-evolve with telomere-binding protein complexes. However, the molecular mechanisms allowing organisms to adapt to new telomeric sequences are difficult to gauge from extant species. Here, we reprogrammed multiple yeast lines to human-...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2026-02-19 | PXD064562 | Pride
Pancreatic beta cells secrete insulin as a response to rising glucose levels in the blood, a process that is known as glucose-stimulated insulin secretion (GSIS). Although GSIS has been extensively studied, not all associated mechanisms are fully understood at the molecular level. In this study, we ...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-07-07 | PXD053750 | Pride
Nutritional supplements like trace element enriched yeasts become increasingly popular to overcome the worldwide problem of zinc (Zn) deficiency. Unlike Selenium-enriched yeast, Zn-enriched yeasts (ZnY) have not yet been authorised in the European Union, as their evaluation is still ongoing demandin...
ORGANISM(S): Saccharomyces pastorianus Saccharomyces cerevisiae (Baker's yeast) 
2025-12-28 | PXD065844 | Pride
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