Sort   by:  
 Page size 
ProteomicsAmyloid-beta Citrullination in Alzheimer's Disease
Amyloid-beta peptides which aggregate and accumulate in Alzheimer’s disease (AD) brain are known to have sequential N-terminal truncations and multiple post-translational modifications (PTM) such as isomerization, pyroglutamate formation, phosphorylation, nitration and dityrosine cross-linking. Here...
ORGANISM(S): Homo sapiens (Human) 
2021-11-24 | PXD025620 | Pride
Citrullination Amyloid-beta Ad 
ProteomicsDistribution of big tau isoforms in the human central and peripheral nervous system
‘Big tau’, a longer isoform of tau is expressed in peripheral nervous system (PNS) and specific regions of the central nervous system (CNS). Big tau distribution across the human nervous system and pathophysiological role remains largely unknown. Here, using mass spectrometry, we demonstrate the big...
ORGANISM(S): Homo sapiens (Human) 
2025-09-15 | PXD059267 | Pride
Tau protein Nerve Proteomics Brain Alzheimer's disease Spinal cord Lc-ms/ms 
ProteomicsQuantitative proteomics of tau and Aβ amyloid in detergent insoluble fractions from Alzheimer’s disease brains
The two hallmarks of Alzheimer’s disease (AD) are A-amyloid- (A) plaques and neurofibrillary tangles marked by phosphorylated tau. There is compelling evidence that aggregating A drives tau accumulation, a process that involves synaptic degeneration leading to cognitive impairment. Conversely there ...
ORGANISM(S): Homo sapiens (Human) 
2022-06-04 | PXD032389 | Pride
In0gel digest Ad Tau 
Sort   by:  
 Page size